Lack of prostaglandin E2-mediated monocyte suppressive activity in newborn and mothers
An excess of adult blood adherent cells (monocytes) inhibits mitogen, antigen and allogeneic cell-induced lymphocyte proliferations. This inhibition is dependent on the number of the adherent monocytes in the cultures and is substantially reduced (by 60%) by indomethacin or anti-PGE2 antiserum. Newb...
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| Veröffentlicht in: | Clinical and experimental immunology 1982-08, Vol.49 (2), p.377-385 |
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| container_title | Clinical and experimental immunology |
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| creator | Fischer, A Durandy, A Mamas, S McCall, E Dray, F Griscelli, C |
| description | An excess of adult blood adherent cells (monocytes) inhibits mitogen, antigen and allogeneic cell-induced lymphocyte proliferations. This inhibition is dependent on the number of the adherent monocytes in the cultures and is substantially reduced (by 60%) by indomethacin or anti-PGE2 antiserum. Newborn monocytes exert only a weak inhibitory effect and produce about eight times less PGE2 than adult monocytes. The production of PGE2 and the suppression can be induced by incubating newborn monocytes with mixed leucocyte culture supernatants. Both monocytes from mothers at the time of delivery and from newborn infants, usually exert a poor suppressive activity related to a low production of PGE2. We strongly suggest that the expression of the PGE2-mediated suppression by monocytes is under the control of activated short-lived suppressor lymphocytes. |
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This inhibition is dependent on the number of the adherent monocytes in the cultures and is substantially reduced (by 60%) by indomethacin or anti-PGE2 antiserum. Newborn monocytes exert only a weak inhibitory effect and produce about eight times less PGE2 than adult monocytes. The production of PGE2 and the suppression can be induced by incubating newborn monocytes with mixed leucocyte culture supernatants. Both monocytes from mothers at the time of delivery and from newborn infants, usually exert a poor suppressive activity related to a low production of PGE2. We strongly suggest that the expression of the PGE2-mediated suppression by monocytes is under the control of activated short-lived suppressor lymphocytes.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 6215198</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Cell Adhesion ; Dinoprostone ; Female ; Fetal Blood - immunology ; Fetal Blood - metabolism ; Humans ; Immunosuppression ; Indomethacin - pharmacology ; Infant, Newborn ; Lymphocyte Activation - drug effects ; Lymphocyte Culture Test, Mixed ; Monocytes - immunology ; Monocytes - metabolism ; Prostaglandins E - biosynthesis ; Prostaglandins E - physiology ; T-Lymphocytes - immunology</subject><ispartof>Clinical and experimental immunology, 1982-08, Vol.49 (2), p.377-385</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536497/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536497/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6215198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fischer, A</creatorcontrib><creatorcontrib>Durandy, A</creatorcontrib><creatorcontrib>Mamas, S</creatorcontrib><creatorcontrib>McCall, E</creatorcontrib><creatorcontrib>Dray, F</creatorcontrib><creatorcontrib>Griscelli, C</creatorcontrib><title>Lack of prostaglandin E2-mediated monocyte suppressive activity in newborn and mothers</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>An excess of adult blood adherent cells (monocytes) inhibits mitogen, antigen and allogeneic cell-induced lymphocyte proliferations. This inhibition is dependent on the number of the adherent monocytes in the cultures and is substantially reduced (by 60%) by indomethacin or anti-PGE2 antiserum. Newborn monocytes exert only a weak inhibitory effect and produce about eight times less PGE2 than adult monocytes. The production of PGE2 and the suppression can be induced by incubating newborn monocytes with mixed leucocyte culture supernatants. Both monocytes from mothers at the time of delivery and from newborn infants, usually exert a poor suppressive activity related to a low production of PGE2. We strongly suggest that the expression of the PGE2-mediated suppression by monocytes is under the control of activated short-lived suppressor lymphocytes.</description><subject>Adult</subject><subject>Cell Adhesion</subject><subject>Dinoprostone</subject><subject>Female</subject><subject>Fetal Blood - immunology</subject><subject>Fetal Blood - metabolism</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Indomethacin - pharmacology</subject><subject>Infant, Newborn</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>Prostaglandins E - biosynthesis</subject><subject>Prostaglandins E - physiology</subject><subject>T-Lymphocytes - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLxDAUhYMo4zj6E4Ss3BXyaG-TjSDD-IABN-q2pGk6E22bmqQj8-8NWERXl8v97jmHc4KWlEORMZbLU7QkhMhMUpKfo4sQ3tMKAGyBFsBoQaVYoret0h_YtXj0LkS169TQ2AFvWNabxqpoGty7weljNDhM4-hNCPZgsNLRHmw84gQP5qt2fsDpNcFxb3y4RGet6oK5mucKvd5vXtaP2fb54Wl9t81GBjRmwOua1EQQwoGxWhIquCikrsGUrFHATUtbJUUJhTAt11y3WgCUbQ4FaMH4Ct3-6I5TnQJrM0Svumr0tlf-WDllq_-Xwe6rnTtUtOCQyzIJ3MwC3n1OJsSqt0GbLvVg3BSqMme5KClJ4PVfp1-LuUn-DdlBcmM</recordid><startdate>19820801</startdate><enddate>19820801</enddate><creator>Fischer, A</creator><creator>Durandy, A</creator><creator>Mamas, S</creator><creator>McCall, E</creator><creator>Dray, F</creator><creator>Griscelli, C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19820801</creationdate><title>Lack of prostaglandin E2-mediated monocyte suppressive activity in newborn and mothers</title><author>Fischer, A ; Durandy, A ; Mamas, S ; McCall, E ; Dray, F ; Griscelli, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-63bb0b08003622b90183859cb6e72da63ef1fa987658ef3c3cfc8667f4656c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Cell Adhesion</topic><topic>Dinoprostone</topic><topic>Female</topic><topic>Fetal Blood - immunology</topic><topic>Fetal Blood - metabolism</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Indomethacin - pharmacology</topic><topic>Infant, Newborn</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>Prostaglandins E - biosynthesis</topic><topic>Prostaglandins E - physiology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fischer, A</creatorcontrib><creatorcontrib>Durandy, A</creatorcontrib><creatorcontrib>Mamas, S</creatorcontrib><creatorcontrib>McCall, E</creatorcontrib><creatorcontrib>Dray, F</creatorcontrib><creatorcontrib>Griscelli, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fischer, A</au><au>Durandy, A</au><au>Mamas, S</au><au>McCall, E</au><au>Dray, F</au><au>Griscelli, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of prostaglandin E2-mediated monocyte suppressive activity in newborn and mothers</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1982-08-01</date><risdate>1982</risdate><volume>49</volume><issue>2</issue><spage>377</spage><epage>385</epage><pages>377-385</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>An excess of adult blood adherent cells (monocytes) inhibits mitogen, antigen and allogeneic cell-induced lymphocyte proliferations. This inhibition is dependent on the number of the adherent monocytes in the cultures and is substantially reduced (by 60%) by indomethacin or anti-PGE2 antiserum. Newborn monocytes exert only a weak inhibitory effect and produce about eight times less PGE2 than adult monocytes. The production of PGE2 and the suppression can be induced by incubating newborn monocytes with mixed leucocyte culture supernatants. Both monocytes from mothers at the time of delivery and from newborn infants, usually exert a poor suppressive activity related to a low production of PGE2. We strongly suggest that the expression of the PGE2-mediated suppression by monocytes is under the control of activated short-lived suppressor lymphocytes.</abstract><cop>England</cop><pmid>6215198</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1982-08, Vol.49 (2), p.377-385 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Cell Adhesion Dinoprostone Female Fetal Blood - immunology Fetal Blood - metabolism Humans Immunosuppression Indomethacin - pharmacology Infant, Newborn Lymphocyte Activation - drug effects Lymphocyte Culture Test, Mixed Monocytes - immunology Monocytes - metabolism Prostaglandins E - biosynthesis Prostaglandins E - physiology T-Lymphocytes - immunology |
| title | Lack of prostaglandin E2-mediated monocyte suppressive activity in newborn and mothers |
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