Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice
A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors pre-treated with cyclophosphamide (Cy) were transferred with syngeneic TC into a hind footpad of a naive mou...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental immunology 1984-05, Vol.56 (2), p.353-360 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 360 |
|---|---|
| container_issue | 2 |
| container_start_page | 353 |
| container_title | Clinical and experimental immunology |
| container_volume | 56 |
| creator | SAKAMOTO, Y SANUI, H YOSHIDA, S NOMOTO, K |
| description | A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors pre-treated with cyclophosphamide (Cy) were transferred with syngeneic TC into a hind footpad of a naive mouse. Antigen specific DFR was successfully transferred by PE cells as early as 3-5 days after immunization and as late as 39 days after immunization. DFR was abolished after treatment of PE cells with anti-0 serum, indicating T cell dependence. No footpad reaction can be elicited in male mice immunized with syngeneic TC without Cy pre-treatment. However, PE cells of those mice can passively transfer footpad reaction locally, suggesting the existence of suppressive mechanism in the donors. Although no suppressive mechanism was disclosed at the present, this LPT system seems a potent tool for further analysis of the regulatory mechanisms. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1536214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>13976113</sourcerecordid><originalsourceid>FETCH-LOGICAL-p321t-a8cae7a224205131105e53f4134e8468799df777901a60222c05f26cb5e1a2603</originalsourceid><addsrcrecordid>eNpVUE1LxDAUDKKs6-pPEHIQb4V8tElzEWTxCxa86FFKNn3djbRJbdKF_nsjlkUv7_GYYebNnKAl5aLIGMvVKVoSQlSmKMnP0UUIn-kUQrAFWghGuJB8iT423ugW9zoEewAcB-1CAwP2Da6h1RPUOE494H0aQwAXbLQHGyccPQ6T24EDa3CEEK0ZWz1gA20bsHW4swYu0Vmj2wBX816h98eHt_Vztnl9elnfb7KeMxozXRoNUqenGSkop5QUUPAmpzyHMhelVKpupJSKUC0IY8yQomHCbAugmgnCV-juV7cftx3UBlwK0lb9YDs9TJXXtvqPOLuvdv5Q0YILRvMkcDsLDP5rTGmqzoafKNqBH0NFuZKCUp6I13-djhZzoQm_mXEdUrFN6tPYcKSVpRQ5VfwbKXmBAA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13976113</pqid></control><display><type>article</type><title>Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>SAKAMOTO, Y ; SANUI, H ; YOSHIDA, S ; NOMOTO, K</creator><creatorcontrib>SAKAMOTO, Y ; SANUI, H ; YOSHIDA, S ; NOMOTO, K</creatorcontrib><description>A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors pre-treated with cyclophosphamide (Cy) were transferred with syngeneic TC into a hind footpad of a naive mouse. Antigen specific DFR was successfully transferred by PE cells as early as 3-5 days after immunization and as late as 39 days after immunization. DFR was abolished after treatment of PE cells with anti-0 serum, indicating T cell dependence. No footpad reaction can be elicited in male mice immunized with syngeneic TC without Cy pre-treatment. However, PE cells of those mice can passively transfer footpad reaction locally, suggesting the existence of suppressive mechanism in the donors. Although no suppressive mechanism was disclosed at the present, this LPT system seems a potent tool for further analysis of the regulatory mechanisms.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 6203673</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Ascitic Fluid - immunology ; Biological and medical sciences ; Cyclophosphamide - pharmacology ; Dose-Response Relationship, Immunologic ; Epitopes - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Hypersensitivity, Delayed ; Immunization, Passive - methods ; Male ; Mammalian male genital system ; Mice ; Mice, Inbred C3H ; Morphology. Physiology ; Spleen - immunology ; T-Lymphocytes - immunology ; Testis - immunology ; Vertebrates: reproduction</subject><ispartof>Clinical and experimental immunology, 1984-05, Vol.56 (2), p.353-360</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536214/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536214/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8876419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6203673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAKAMOTO, Y</creatorcontrib><creatorcontrib>SANUI, H</creatorcontrib><creatorcontrib>YOSHIDA, S</creatorcontrib><creatorcontrib>NOMOTO, K</creatorcontrib><title>Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors pre-treated with cyclophosphamide (Cy) were transferred with syngeneic TC into a hind footpad of a naive mouse. Antigen specific DFR was successfully transferred by PE cells as early as 3-5 days after immunization and as late as 39 days after immunization. DFR was abolished after treatment of PE cells with anti-0 serum, indicating T cell dependence. No footpad reaction can be elicited in male mice immunized with syngeneic TC without Cy pre-treatment. However, PE cells of those mice can passively transfer footpad reaction locally, suggesting the existence of suppressive mechanism in the donors. Although no suppressive mechanism was disclosed at the present, this LPT system seems a potent tool for further analysis of the regulatory mechanisms.</description><subject>Animals</subject><subject>Ascitic Fluid - immunology</subject><subject>Biological and medical sciences</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Epitopes - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypersensitivity, Delayed</subject><subject>Immunization, Passive - methods</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Morphology. Physiology</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Testis - immunology</subject><subject>Vertebrates: reproduction</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1LxDAUDKKs6-pPEHIQb4V8tElzEWTxCxa86FFKNn3djbRJbdKF_nsjlkUv7_GYYebNnKAl5aLIGMvVKVoSQlSmKMnP0UUIn-kUQrAFWghGuJB8iT423ugW9zoEewAcB-1CAwP2Da6h1RPUOE494H0aQwAXbLQHGyccPQ6T24EDa3CEEK0ZWz1gA20bsHW4swYu0Vmj2wBX816h98eHt_Vztnl9elnfb7KeMxozXRoNUqenGSkop5QUUPAmpzyHMhelVKpupJSKUC0IY8yQomHCbAugmgnCV-juV7cftx3UBlwK0lb9YDs9TJXXtvqPOLuvdv5Q0YILRvMkcDsLDP5rTGmqzoafKNqBH0NFuZKCUp6I13-djhZzoQm_mXEdUrFN6tPYcKSVpRQ5VfwbKXmBAA</recordid><startdate>19840501</startdate><enddate>19840501</enddate><creator>SAKAMOTO, Y</creator><creator>SANUI, H</creator><creator>YOSHIDA, S</creator><creator>NOMOTO, K</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>19840501</creationdate><title>Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice</title><author>SAKAMOTO, Y ; SANUI, H ; YOSHIDA, S ; NOMOTO, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-a8cae7a224205131105e53f4134e8468799df777901a60222c05f26cb5e1a2603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Ascitic Fluid - immunology</topic><topic>Biological and medical sciences</topic><topic>Cyclophosphamide - pharmacology</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Epitopes - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypersensitivity, Delayed</topic><topic>Immunization, Passive - methods</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Morphology. Physiology</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Testis - immunology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAKAMOTO, Y</creatorcontrib><creatorcontrib>SANUI, H</creatorcontrib><creatorcontrib>YOSHIDA, S</creatorcontrib><creatorcontrib>NOMOTO, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAKAMOTO, Y</au><au>SANUI, H</au><au>YOSHIDA, S</au><au>NOMOTO, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1984-05-01</date><risdate>1984</risdate><volume>56</volume><issue>2</issue><spage>353</spage><epage>360</epage><pages>353-360</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors pre-treated with cyclophosphamide (Cy) were transferred with syngeneic TC into a hind footpad of a naive mouse. Antigen specific DFR was successfully transferred by PE cells as early as 3-5 days after immunization and as late as 39 days after immunization. DFR was abolished after treatment of PE cells with anti-0 serum, indicating T cell dependence. No footpad reaction can be elicited in male mice immunized with syngeneic TC without Cy pre-treatment. However, PE cells of those mice can passively transfer footpad reaction locally, suggesting the existence of suppressive mechanism in the donors. Although no suppressive mechanism was disclosed at the present, this LPT system seems a potent tool for further analysis of the regulatory mechanisms.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>6203673</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9104 |
| ispartof | Clinical and experimental immunology, 1984-05, Vol.56 (2), p.353-360 |
| issn | 0009-9104 1365-2249 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1536214 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Ascitic Fluid - immunology Biological and medical sciences Cyclophosphamide - pharmacology Dose-Response Relationship, Immunologic Epitopes - immunology Female Fundamental and applied biological sciences. Psychology Hypersensitivity, Delayed Immunization, Passive - methods Male Mammalian male genital system Mice Mice, Inbred C3H Morphology. Physiology Spleen - immunology T-Lymphocytes - immunology Testis - immunology Vertebrates: reproduction |
| title | Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T03%3A28%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Local%20passive%20transfer%20of%20delayed%20type%20hypersensitivity%20to%20syngeneic%20testicular%20cells%20in%20mice&rft.jtitle=Clinical%20and%20experimental%20immunology&rft.au=SAKAMOTO,%20Y&rft.date=1984-05-01&rft.volume=56&rft.issue=2&rft.spage=353&rft.epage=360&rft.pages=353-360&rft.issn=0009-9104&rft.eissn=1365-2249&rft.coden=CEXIAL&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E13976113%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13976113&rft_id=info:pmid/6203673&rfr_iscdi=true |