Dihydropyrimidine amidohydrolases and dihydroorotases share the same origin and several enzymatic properties

Slime mold, plant and insect dihydropyrimidine amidohydrolases (DHPases, EC 3.5.2.2), which catalyze the second step of pyrimidine and several anti‐cancer drug degradations, were cloned and shown to functionally replace a defective DHPase enzyme in the yeast Saccharomyces kluyveri. The yeast and sli...

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Veröffentlicht in:	Nucleic acids research 2003-03, Vol.31 (6), p.1683-1692
Hauptverfasser:	Gojkovic, Zoran, Rislund, Lise, Andersen, Birgit, Sandrini, Michael P. B., Cook, Paul F., Schnackerz, Klaus D., Piškur, Jure
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Amidohydrolases - metabolism Animals Arabidopsis - enzymology Arabidopsis - genetics Dictyostelium - enzymology Dictyostelium - genetics Dihydroorotase - genetics Dihydroorotase - metabolism Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Escherichia coli - genetics Evolution, Molecular Kinetics Phylogeny Recombinant Proteins - genetics Recombinant Proteins - metabolism Saccharomyces - enzymology Saccharomyces - genetics Substrate Specificity
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