SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Posttranslational modification of histones has emerged as a key regulatory signal in eukaryotic gene expression. Recent genetic and biochemical studies link H3-lysine 9 (H3-K9) methylation to HP1-mediated heterochromatin formation and gene silencing. However, the mechanisms that target and coordinat...

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Veröffentlicht in:	Genes & development 2002-04, Vol.16 (8), p.919-932
Hauptverfasser:	Schultz, David C, Ayyanathan, Kasirajan, Negorev, Dmitri, Maul, Gerd G, Rauscher, 3rd, Frank J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Chromosomal Proteins, Non-Histone - metabolism DNA-Binding Proteins - metabolism Euchromatin - metabolism Fluorescent Antibody Technique, Indirect Gene Silencing - physiology Histones - metabolism HP-1 gene Humans KAP-1 gene Lysine - metabolism Macromolecular Substances Methylation Mice Molecular Sequence Data Nuclear Proteins Protein Binding - physiology Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Structure, Tertiary - physiology Repressor Proteins - metabolism Research Paper Sequence Homology, Amino Acid SETDB1 gene Substrate Specificity Transcription Factors Tripartite Motif-Containing Protein 28 Two-Hybrid System Techniques Zinc Fingers
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