POLIOMYELITIS AND PARENTERAL INJECTIONS—A Review of Recent Literature

Data presented in the literature as to the relationship of poliomyelitis and recent prior injections include several aspects. the coincidence of paralysis in the same site as a recent injection has been considered the most definitive evidence. The fact of an inordinately large number of cases of paralysis of an arm where a recent previous antigen injection was recorded offered less specific corroboration. The larger number of cases among persons who had had an injection in the month preceding onset than among persons with injections in more distant months was noted. This observation was supported when similar information was obtained in a comparison of injection histories for persons who had the disease with the histories of persons who did not have it. The interval between injection and onset among persons who had the disease within a month of injection suggested something other than chance relationship. There is limited information indicating increased severity of paralysis in the injected limb. Evidence is divided on whether or not there is more paralytic disease among patients with recent injections. Similarly, the evidence is no more than suggestive with regard to increased severity of spinal paralytic disease. The mechanism or nature of such a phenomenon is unexplained. However, as Anderson and Skaar said, “considerable attention must be attached to the fact of uniformity of results in a series of independent observations even though each may be small.”