Electrical and Freeze-Fracture Analysis of the Effects of Ionic Cadmium on Cell Membranes of Human Proximal Tubule Cells

We previously reported that cell cultures of human proximal tubule (HPT) cells respond to ionic cadmium in a manner consistent with well-defined Cd2+-elicited responses reported for in vivo systems. However, one unique finding was that the transepithelial electrical resistance and tight junction sea...

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Veröffentlicht in:	Environmental health perspectives 1993-11, Vol.101 (6), p.510-516
Hauptverfasser:	Hazen-Martin, Debra J., Todd, John H., Sens, Mary Ann, Khan, Wasil, Bylander, John E., Smyth, Brendan J., Sens, Donald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry 560300 - Chemicals Metabolism & Toxicology BASIC BIOLOGICAL SCIENCES BIOELECTRICITY BIOLOGICAL EFFECTS BODY CADMIUM Cadmium - pharmacology Cations, Divalent - pharmacology CELL CONSTITUENTS Cell culture techniques CELL CULTURES Cell lines Cell Membrane - drug effects CELL MEMBRANES Cell Survival - drug effects Cells, Cultured Cultured cells Cyclic AMP - metabolism ELECTRIC CONDUCTIVITY Electric Impedance ELECTRICAL PROPERTIES ELECTRICITY ELECTROPHYSIOLOGY ELEMENTS Epithelial cells Freeze Fracturing Humans Intercellular junctions JUNCTIONS Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects KIDNEYS MEMBRANES METALS ORGANS PHYSICAL PROPERTIES PHYSIOLOGY Proximal tubules RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Sertoli cells Sodium-Potassium-Exchanging ATPase - metabolism Tight junctions TOXICITY TUBULES
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