Enhanced Response to Ozone Exposure during the Follicular Phase of the Menstrual Cycle
Exposure to ozone ( O3), a toxic component of photochemical smog, results in significant airway inflammation, respiratory discomfort, and pulmonary function impairment. These effects can be reduced via pretreatment with anti-inflammatory agents. Progesterone, a gonadal steroid, is known to reduce ge...
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| Veröffentlicht in: | Environmental health perspectives 1993-08, Vol.101 (3), p.242-244 |
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| creator | Fox, Susan D. Adams, William C. Brookes, Katherine A. Lasley, Bill L. |
| description | Exposure to ozone ( O3), a toxic component of photochemical smog, results in significant airway inflammation, respiratory discomfort, and pulmonary function impairment. These effects can be reduced via pretreatment with anti-inflammatory agents. Progesterone, a gonadal steroid, is known to reduce general inflammation in the uterine endometrium. However, it is not known whether fluctuations in blood levels of progesterone, which are experienced during the normal female menstrual cycle, could alter O3inflammatory-induced pulmonary responses. In this study, we tested the hypothesis that young, adult females are more responsive to O3inhalation with respect to pulmonary function impairment during their follicular (F) menstrual phase when progesterone levels are lowest than during their mid-luteal (ML) phase when progesterone levels are highest. Nine subjects with normal ovarian function were exposed in random order for 1 hr each to filtered air and to 0.30 ppm O3in their F and ML menstrual phases. Ozone responsiveness was measured by percent change in pulmonary function from pre- to postexposure. Significant gas concentration effects (filtered air versus O3) were observed for forced vital capacity (FVC), forced expiratory volume in 1 sec ( FEV1), and forced expiratory flow between 25 and 75% of FVC ( FEF25-75; p |
| doi_str_mv | 10.1289/ehp.93101242 |
| format | Article |
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These effects can be reduced via pretreatment with anti-inflammatory agents. Progesterone, a gonadal steroid, is known to reduce general inflammation in the uterine endometrium. However, it is not known whether fluctuations in blood levels of progesterone, which are experienced during the normal female menstrual cycle, could alter O3inflammatory-induced pulmonary responses. In this study, we tested the hypothesis that young, adult females are more responsive to O3inhalation with respect to pulmonary function impairment during their follicular (F) menstrual phase when progesterone levels are lowest than during their mid-luteal (ML) phase when progesterone levels are highest. Nine subjects with normal ovarian function were exposed in random order for 1 hr each to filtered air and to 0.30 ppm O3in their F and ML menstrual phases. Ozone responsiveness was measured by percent change in pulmonary function from pre- to postexposure. Significant gas concentration effects (filtered air versus O3) were observed for forced vital capacity (FVC), forced expiratory volume in 1 sec ( FEV1), and forced expiratory flow between 25 and 75% of FVC ( FEF25-75; p<.05). More importantly, the pulmonary function flow rates, FEV1and FEF25-75, showed a significant menstrual phase and gas concentration interaction effect, with larger decrements observed in the F menstrual phase when progesterone concentrations were significantly lower. We conclude that young, adult females appear to be more responsive to acute O3exposure during the F phase than during the ML phase of their menstrual cycles. This difference in pulmonary function response could be related to the anti-inflammatory effects of increased progesterone concentrations during the luteal phase.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.93101242</identifier><identifier>PMID: 8404762</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>551000 - Physiological Systems ; 560300 - Chemicals Metabolism & Toxicology ; Administration, Inhalation ; Adult ; ANTIPYRETICS ; BASIC BIOLOGICAL SCIENCES ; BIOLOGICAL EFFECTS ; BODY ; Brief Reports ; CENTRAL NERVOUS SYSTEM DEPRESSANTS ; DRUGS ; Endometrium ; ENVIRONMENTAL EXPOSURE ; Estrogens - urine ; Female ; FEMALES ; Follicular Phase - drug effects ; Follicular Phase - physiology ; Follicular Phase - urine ; HORMONES ; Humans ; INFLAMMATION ; KETONES ; Lung - drug effects ; Lung - physiology ; LUNGS ; Luteal Phase - drug effects ; Luteal Phase - physiology ; Luteal Phase - urine ; Male ; MENSTRUAL CYCLE ; ORGANIC COMPOUNDS ; ORGANS ; OZONE ; Ozone - adverse effects ; PATHOLOGICAL CHANGES ; PREGNANES ; PROGESTERONE ; Progesterone - urine ; Prostaglandins ; Prostaglandins - metabolism ; Pulmonary functions ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RESPIRATORY SYSTEM ; RESPONSE MODIFYING FACTORS ; SMOG ; STEROID HORMONES ; STEROIDS ; SYMPTOMS ; Vital capacity</subject><ispartof>Environmental health perspectives, 1993-08, Vol.101 (3), p.242-244</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3502-6341eb770bd9cf4ff55d24bd702cd40d7b92c235554df98fec84dab55790aa253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3431550$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3431550$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8404762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5977860$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, Susan D.</creatorcontrib><creatorcontrib>Adams, William C.</creatorcontrib><creatorcontrib>Brookes, Katherine A.</creatorcontrib><creatorcontrib>Lasley, Bill L.</creatorcontrib><title>Enhanced Response to Ozone Exposure during the Follicular Phase of the Menstrual Cycle</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Exposure to ozone ( O3), a toxic component of photochemical smog, results in significant airway inflammation, respiratory discomfort, and pulmonary function impairment. These effects can be reduced via pretreatment with anti-inflammatory agents. Progesterone, a gonadal steroid, is known to reduce general inflammation in the uterine endometrium. However, it is not known whether fluctuations in blood levels of progesterone, which are experienced during the normal female menstrual cycle, could alter O3inflammatory-induced pulmonary responses. In this study, we tested the hypothesis that young, adult females are more responsive to O3inhalation with respect to pulmonary function impairment during their follicular (F) menstrual phase when progesterone levels are lowest than during their mid-luteal (ML) phase when progesterone levels are highest. Nine subjects with normal ovarian function were exposed in random order for 1 hr each to filtered air and to 0.30 ppm O3in their F and ML menstrual phases. Ozone responsiveness was measured by percent change in pulmonary function from pre- to postexposure. Significant gas concentration effects (filtered air versus O3) were observed for forced vital capacity (FVC), forced expiratory volume in 1 sec ( FEV1), and forced expiratory flow between 25 and 75% of FVC ( FEF25-75; p<.05). More importantly, the pulmonary function flow rates, FEV1and FEF25-75, showed a significant menstrual phase and gas concentration interaction effect, with larger decrements observed in the F menstrual phase when progesterone concentrations were significantly lower. We conclude that young, adult females appear to be more responsive to acute O3exposure during the F phase than during the ML phase of their menstrual cycles. This difference in pulmonary function response could be related to the anti-inflammatory effects of increased progesterone concentrations during the luteal phase.</description><subject>551000 - Physiological Systems</subject><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>ANTIPYRETICS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>Brief Reports</subject><subject>CENTRAL NERVOUS SYSTEM DEPRESSANTS</subject><subject>DRUGS</subject><subject>Endometrium</subject><subject>ENVIRONMENTAL EXPOSURE</subject><subject>Estrogens - urine</subject><subject>Female</subject><subject>FEMALES</subject><subject>Follicular Phase - drug effects</subject><subject>Follicular Phase - physiology</subject><subject>Follicular Phase - urine</subject><subject>HORMONES</subject><subject>Humans</subject><subject>INFLAMMATION</subject><subject>KETONES</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>LUNGS</subject><subject>Luteal Phase - drug effects</subject><subject>Luteal Phase - physiology</subject><subject>Luteal Phase - urine</subject><subject>Male</subject><subject>MENSTRUAL CYCLE</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>OZONE</subject><subject>Ozone - adverse effects</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PREGNANES</subject><subject>PROGESTERONE</subject><subject>Progesterone - urine</subject><subject>Prostaglandins</subject><subject>Prostaglandins - metabolism</subject><subject>Pulmonary functions</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RESPIRATORY SYSTEM</subject><subject>RESPONSE MODIFYING FACTORS</subject><subject>SMOG</subject><subject>STEROID HORMONES</subject><subject>STEROIDS</subject><subject>SYMPTOMS</subject><subject>Vital capacity</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rFTEUhoMo9ba6cysE6dKpJ1-TyUaQy20VKhVRtyGTnOlMmSZDMiNtf72jty11FTjvw3PCeQl5w-CE8cZ8wH46MYIB45I_IxumFK-M4fI52QAYVtW6Vi_JYSlXAMCauj4gB40EqWu-Ib92sXfRY6DfsUwpFqRzohd3KSLd3UypLBlpWPIQL-ncIz1N4zj4ZXSZfuvdSqfu3_wrxjLnxY10e-tHfEVedG4s-Pr-PSI_T3c_tp-r84uzL9tP55UXCnhVC8mw1RraYHwnu06pwGUbNHAfJATdGu65UErJ0JmmQ9_I4FqltAHnuBJH5OPeOy3tNQaPcc5utFMerl2-tckN9v8kDr29TL8tU8xozVfBu70glXmwxQ8z-t6nGNHPVq1IU8MKvd9DPqdSMnaPCxjYvx3YtQP70MGKv336qUf4_uhrfrzPr8qc8lMXF6CtkGLtEMQfdr2Oww</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Fox, Susan D.</creator><creator>Adams, William C.</creator><creator>Brookes, Katherine A.</creator><creator>Lasley, Bill L.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19930801</creationdate><title>Enhanced Response to Ozone Exposure during the Follicular Phase of the Menstrual Cycle</title><author>Fox, Susan D. ; Adams, William C. ; Brookes, Katherine A. ; Lasley, Bill L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3502-6341eb770bd9cf4ff55d24bd702cd40d7b92c235554df98fec84dab55790aa253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>551000 - Physiological Systems</topic><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>ANTIPYRETICS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>Brief Reports</topic><topic>CENTRAL NERVOUS SYSTEM DEPRESSANTS</topic><topic>DRUGS</topic><topic>Endometrium</topic><topic>ENVIRONMENTAL EXPOSURE</topic><topic>Estrogens - urine</topic><topic>Female</topic><topic>FEMALES</topic><topic>Follicular Phase - drug effects</topic><topic>Follicular Phase - physiology</topic><topic>Follicular Phase - urine</topic><topic>HORMONES</topic><topic>Humans</topic><topic>INFLAMMATION</topic><topic>KETONES</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>LUNGS</topic><topic>Luteal Phase - drug effects</topic><topic>Luteal Phase - physiology</topic><topic>Luteal Phase - urine</topic><topic>Male</topic><topic>MENSTRUAL CYCLE</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>OZONE</topic><topic>Ozone - adverse effects</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PREGNANES</topic><topic>PROGESTERONE</topic><topic>Progesterone - urine</topic><topic>Prostaglandins</topic><topic>Prostaglandins - metabolism</topic><topic>Pulmonary functions</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RESPIRATORY SYSTEM</topic><topic>RESPONSE MODIFYING FACTORS</topic><topic>SMOG</topic><topic>STEROID HORMONES</topic><topic>STEROIDS</topic><topic>SYMPTOMS</topic><topic>Vital capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, Susan D.</creatorcontrib><creatorcontrib>Adams, William C.</creatorcontrib><creatorcontrib>Brookes, Katherine A.</creatorcontrib><creatorcontrib>Lasley, Bill L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, Susan D.</au><au>Adams, William C.</au><au>Brookes, Katherine A.</au><au>Lasley, Bill L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Response to Ozone Exposure during the Follicular Phase of the Menstrual Cycle</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>101</volume><issue>3</issue><spage>242</spage><epage>244</epage><pages>242-244</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Exposure to ozone ( O3), a toxic component of photochemical smog, results in significant airway inflammation, respiratory discomfort, and pulmonary function impairment. These effects can be reduced via pretreatment with anti-inflammatory agents. Progesterone, a gonadal steroid, is known to reduce general inflammation in the uterine endometrium. However, it is not known whether fluctuations in blood levels of progesterone, which are experienced during the normal female menstrual cycle, could alter O3inflammatory-induced pulmonary responses. In this study, we tested the hypothesis that young, adult females are more responsive to O3inhalation with respect to pulmonary function impairment during their follicular (F) menstrual phase when progesterone levels are lowest than during their mid-luteal (ML) phase when progesterone levels are highest. Nine subjects with normal ovarian function were exposed in random order for 1 hr each to filtered air and to 0.30 ppm O3in their F and ML menstrual phases. Ozone responsiveness was measured by percent change in pulmonary function from pre- to postexposure. Significant gas concentration effects (filtered air versus O3) were observed for forced vital capacity (FVC), forced expiratory volume in 1 sec ( FEV1), and forced expiratory flow between 25 and 75% of FVC ( FEF25-75; p<.05). More importantly, the pulmonary function flow rates, FEV1and FEF25-75, showed a significant menstrual phase and gas concentration interaction effect, with larger decrements observed in the F menstrual phase when progesterone concentrations were significantly lower. We conclude that young, adult females appear to be more responsive to acute O3exposure during the F phase than during the ML phase of their menstrual cycles. This difference in pulmonary function response could be related to the anti-inflammatory effects of increased progesterone concentrations during the luteal phase.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>8404762</pmid><doi>10.1289/ehp.93101242</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 551000 - Physiological Systems 560300 - Chemicals Metabolism & Toxicology Administration, Inhalation Adult ANTIPYRETICS BASIC BIOLOGICAL SCIENCES BIOLOGICAL EFFECTS BODY Brief Reports CENTRAL NERVOUS SYSTEM DEPRESSANTS DRUGS Endometrium ENVIRONMENTAL EXPOSURE Estrogens - urine Female FEMALES Follicular Phase - drug effects Follicular Phase - physiology Follicular Phase - urine HORMONES Humans INFLAMMATION KETONES Lung - drug effects Lung - physiology LUNGS Luteal Phase - drug effects Luteal Phase - physiology Luteal Phase - urine Male MENSTRUAL CYCLE ORGANIC COMPOUNDS ORGANS OZONE Ozone - adverse effects PATHOLOGICAL CHANGES PREGNANES PROGESTERONE Progesterone - urine Prostaglandins Prostaglandins - metabolism Pulmonary functions RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESPIRATORY SYSTEM RESPONSE MODIFYING FACTORS SMOG STEROID HORMONES STEROIDS SYMPTOMS Vital capacity |
| title | Enhanced Response to Ozone Exposure during the Follicular Phase of the Menstrual Cycle |
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