Molecular Genetic Analysis of the Cytochrome P450-Debrisoquine Hydroxylase Locus and Association with Cancer Susceptibility

The cytochrome P450-dependent monooxygenases play a central role in the metabolism of chemical carcinogens. The action of these enzymes can lead to either carcinogen detoxication or activation. Differences in P450 expression in animal models give rise to large differences in susceptibility to chemic...

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Veröffentlicht in:	Environmental health perspectives 1992-11, Vol.98, p.107-112
Hauptverfasser:	C. A. Dale Smith, Moss, Julie E., Gough, Alan C., Spurr, Nigel K., Wolf, C. Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence carcinoma Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 debrisoquine hydroxylase Disease Susceptibility DNA DNA Mutational Analysis frequency Genetic loci Genetic mutation Genetic Polymorphisms in Xenobiotic-Metabolizing Enzymes and Cancer Susceptibility Genotypes Hems Human genetics Humans Lung neoplasms man Metabolism Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular Sequence Data mutation Neoplasms - enzymology Neoplasms - genetics phenotypes Polymerase Chain Reaction polymorphism Polymorphism, Genetic susceptibility
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