Immunohistochemical Detection of Pulmonary Cytochrome P450IA and Metabolic Activities Associated with P450IA1 and P450IA2 Isozymes in Lung Cancer Patients

The main polycyclic aromatic hydrocarbon-inducible cytochrome P450 was studied in lung tissue from 57 lung cancer patients by immunohistochemistry, using a monoclonal antibody (1-7-1) that recognizes P450IA1 and P450IA2 isozymes. The intensity of immunostaining was compared with the pulmonary activi...

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Veröffentlicht in:	Environmental health perspectives 1992-11, Vol.98, p.179-182
Hauptverfasser:	Anttila, Sisko, Vainio, Harri, Hietanen, Eino, Camus, Anne-Marie, Malaveille, Christian, Brun, Gisele, Husgafvel-Pursiainen, Kirsti, Heikkilä, Lasse, Karjalainen, Antti, Bartsch, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - enzymology Adult Aged Anti smoking movements Aryl Hydrocarbon Hydroxylases - metabolism Bronchogenic carcinoma Carcinoma, Bronchogenic - chemically induced Carcinoma, Bronchogenic - enzymology Carcinoma, Non-Small-Cell Lung - chemically induced Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Small Cell - chemically induced Carcinoma, Small Cell - enzymology Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - enzymology Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - metabolism Cytochromes Enzymes Female Humans Lung neoplasms Lung Neoplasms - chemically induced Lung Neoplasms - enzymology Lungs Male Manuscripts from Presented Posters: Molecular, Chromosomal, and Cellular Susceptibility Markers in the Multi-Stage Carcinogenesis Process in Humans Metabolism Metabolites Middle Aged Oxidoreductases - analysis Oxidoreductases - metabolism Pulmonary alveoli Smoking - adverse effects Tobacco smoking
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