Effects of Instilled Fibrogenic Particles on the Clonal Growth of Murine Pulmonary Alveolar Macrophages

Murine pulmonary alveolar macrophages (PAM) form macrophage colonies in vitro with colony-stimulating factors, which stimulate the clonal growth of radioresistant alveolar colony-forming cells (AL-CFC). The toxic effects of fibrogenic mineral dust particles on AL-CFC were investigated after intratra...

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Veröffentlicht in:	Environmental health perspectives 1992-07, Vol.97, p.159-161
Hauptverfasser:	Oghiso, Yoichi, Yamada, Yutaka, Shibata, Yoshimi
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 > Biochemistry ANIMAL CELLS Animals ASBESTOS Asbestos - toxicity BASIC BIOLOGICAL SCIENCES BIOLOGICAL PATHWAYS Cell culture techniques Cell Division - drug effects Cell growth CHALCOGENIDES CLEARANCE Clone Cells - cytology COLONY FORMATION CONNECTIVE TISSUE CELLS DOSE-RESPONSE RELATIONSHIPS EXCRETION Female Intracellular Particle Dissolution LUNG CLEARANCE Lungs MACROPHAGES Macrophages, Alveolar - cytology Mice Mice, Inbred C3H MINERALS Neutrophils OXIDE MINERALS OXIDES OXYGEN COMPOUNDS PHAGOCYTES Pulmonary alveoli RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SILICA SILICON COMPOUNDS Silicon Dioxide - toxicity SILICON OXIDES SOMATIC CELLS 560300 > Chemicals Metabolism & Toxicology Stem cells Titanium - toxicity TOXICITY
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