The reversibility of mitotic exit in vertebrate cells

Cells proceed through the cell cycle in a highly ordered and unidirectional manner; however, if the degradation of cyclin B is prevented as cells exit mitosis and its associated Cdk1 kinase activity restored, cells can reverse back to M phase. A guiding hypothesis for cell-cycle regulation asserts t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature 2006-04, Vol.440 (7086), p.954-958
Hauptverfasser:	Potapova, Tamara A., Daum, John R., Pittman, Bradley D., Hudson, Joanna R., Jones, Tara N., Satinover, David L., Stukenberg, P. Todd, Gorbsky, Gary J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CDC2 Protein Kinase - antagonists & inhibitors CDC2 Protein Kinase - metabolism Cell cycle Cell cycle, cell proliferation Cell Line Cell physiology Cells Cells, Cultured Chromatin. Chromosome Chromosomes Cyclin B - metabolism Cytokinesis - drug effects Degradation Enzymes Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Furrows G1 Phase - drug effects HeLa Cells Humanities and Social Sciences Humans Inhibitors Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - enzymology Keratinocytes - metabolism letter Metaphase - drug effects Mitosis - drug effects Mitosis - physiology Models, Biological Molecular and cellular biology Molecular genetics multidisciplinary Nocodazole - pharmacology Piperidines - pharmacology Proteasome Endopeptidase Complex - metabolism Science Science (multidisciplinary) Vertebrates Xenopus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!