Growth and endocrine sequelae of craniopharyngioma
The growth and endocrine sequelae of 75 children (33 girls and 42 boys) with craniopharyngioma, treated from 1973 to 1994, were studied by retrospective review and by follow up assessment in 66 survivors, with a mean time from initial surgery of 6.7 years (range 1.5 to 19.8 years). Although infreque...
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| Veröffentlicht in: | Archives of disease in childhood 1996-08, Vol.75 (2), p.108-114 |
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| creator | DeVile, C J Grant, D B Hayward, R D Stanhope, R |
| description | The growth and endocrine sequelae of 75 children (33 girls and 42 boys) with craniopharyngioma, treated from 1973 to 1994, were studied by retrospective review and by follow up assessment in 66 survivors, with a mean time from initial surgery of 6.7 years (range 1.5 to 19.8 years). Although infrequently complained of, 71% of patients had symptoms to suggest an endocrinopathy at diagnosis. After surgery, multiple endocrinopathies were almost universal, such that 75% of children had panhypopituitarism at follow up. Hypoadrenal crises in association with intercurrent illness contributed significantly to morbidity and mortality, as did the metabolic consequences of concomitant antidiuretic hormone (ADH) insufficiency and absent thirst. Final height in 25 patients was significantly below genetic target height, particularly in the girls, with loss of height potential occurring during the pubertal years. The endocrine morbidity associated with craniopharyngioma and its treatment remains high but manageable with appropriate hormone replacement. However, the combination of ADH insufficiency and an impaired sense of thirst following aggressive surgery and severe hypothalamic injury remains one of the most complex management problems. |
| doi_str_mv | 10.1136/adc.75.2.108 |
| format | Article |
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Although infrequently complained of, 71% of patients had symptoms to suggest an endocrinopathy at diagnosis. After surgery, multiple endocrinopathies were almost universal, such that 75% of children had panhypopituitarism at follow up. Hypoadrenal crises in association with intercurrent illness contributed significantly to morbidity and mortality, as did the metabolic consequences of concomitant antidiuretic hormone (ADH) insufficiency and absent thirst. Final height in 25 patients was significantly below genetic target height, particularly in the girls, with loss of height potential occurring during the pubertal years. The endocrine morbidity associated with craniopharyngioma and its treatment remains high but manageable with appropriate hormone replacement. However, the combination of ADH insufficiency and an impaired sense of thirst following aggressive surgery and severe hypothalamic injury remains one of the most complex management problems.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.75.2.108</identifier><identifier>PMID: 8869189</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Anthropometry ; Biological and medical sciences ; Body Height ; Child ; Child, Preschool ; Craniopharyngioma - surgery ; Endocrine System Diseases - etiology ; Female ; Follow-Up Studies ; Growth Disorders - etiology ; Growth Hormone - therapeutic use ; Humans ; Hypothalamo-Hypophyseal System - physiopathology ; Infant ; Male ; Medical sciences ; Morbidity ; Neurology ; Paraneoplastic Syndromes - etiology ; Pituitary Diseases - etiology ; Pituitary Neoplasms - surgery ; Postoperative Complications ; Puberty ; Retrospective Studies ; Surgery ; Survivors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Archives of disease in childhood, 1996-08, Vol.75 (2), p.108-114</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Aug 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-58d04a49acba4e2efcd69dfea14fcda65c5bf81c569356f154e7ef06107b6a4c3</citedby><cites>FETCH-LOGICAL-b506t-58d04a49acba4e2efcd69dfea14fcda65c5bf81c569356f154e7ef06107b6a4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511642/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511642/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3187885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8869189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeVile, C J</creatorcontrib><creatorcontrib>Grant, D B</creatorcontrib><creatorcontrib>Hayward, R D</creatorcontrib><creatorcontrib>Stanhope, R</creatorcontrib><title>Growth and endocrine sequelae of craniopharyngioma</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>The growth and endocrine sequelae of 75 children (33 girls and 42 boys) with craniopharyngioma, treated from 1973 to 1994, were studied by retrospective review and by follow up assessment in 66 survivors, with a mean time from initial surgery of 6.7 years (range 1.5 to 19.8 years). Although infrequently complained of, 71% of patients had symptoms to suggest an endocrinopathy at diagnosis. After surgery, multiple endocrinopathies were almost universal, such that 75% of children had panhypopituitarism at follow up. Hypoadrenal crises in association with intercurrent illness contributed significantly to morbidity and mortality, as did the metabolic consequences of concomitant antidiuretic hormone (ADH) insufficiency and absent thirst. Final height in 25 patients was significantly below genetic target height, particularly in the girls, with loss of height potential occurring during the pubertal years. The endocrine morbidity associated with craniopharyngioma and its treatment remains high but manageable with appropriate hormone replacement. However, the combination of ADH insufficiency and an impaired sense of thirst following aggressive surgery and severe hypothalamic injury remains one of the most complex management problems.</description><subject>Adolescent</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Craniopharyngioma - surgery</subject><subject>Endocrine System Diseases - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Growth Disorders - etiology</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morbidity</subject><subject>Neurology</subject><subject>Paraneoplastic Syndromes - etiology</subject><subject>Pituitary Diseases - etiology</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Postoperative Complications</subject><subject>Puberty</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survivors</subject><subject>Tumors of the nervous system. 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Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeVile, C J</creatorcontrib><creatorcontrib>Grant, D B</creatorcontrib><creatorcontrib>Hayward, R D</creatorcontrib><creatorcontrib>Stanhope, R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeVile, C J</au><au>Grant, D B</au><au>Hayward, R D</au><au>Stanhope, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth and endocrine sequelae of craniopharyngioma</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>75</volume><issue>2</issue><spage>108</spage><epage>114</epage><pages>108-114</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>The growth and endocrine sequelae of 75 children (33 girls and 42 boys) with craniopharyngioma, treated from 1973 to 1994, were studied by retrospective review and by follow up assessment in 66 survivors, with a mean time from initial surgery of 6.7 years (range 1.5 to 19.8 years). Although infrequently complained of, 71% of patients had symptoms to suggest an endocrinopathy at diagnosis. After surgery, multiple endocrinopathies were almost universal, such that 75% of children had panhypopituitarism at follow up. Hypoadrenal crises in association with intercurrent illness contributed significantly to morbidity and mortality, as did the metabolic consequences of concomitant antidiuretic hormone (ADH) insufficiency and absent thirst. Final height in 25 patients was significantly below genetic target height, particularly in the girls, with loss of height potential occurring during the pubertal years. The endocrine morbidity associated with craniopharyngioma and its treatment remains high but manageable with appropriate hormone replacement. However, the combination of ADH insufficiency and an impaired sense of thirst following aggressive surgery and severe hypothalamic injury remains one of the most complex management problems.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>8869189</pmid><doi>10.1136/adc.75.2.108</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Anthropometry Biological and medical sciences Body Height Child Child, Preschool Craniopharyngioma - surgery Endocrine System Diseases - etiology Female Follow-Up Studies Growth Disorders - etiology Growth Hormone - therapeutic use Humans Hypothalamo-Hypophyseal System - physiopathology Infant Male Medical sciences Morbidity Neurology Paraneoplastic Syndromes - etiology Pituitary Diseases - etiology Pituitary Neoplasms - surgery Postoperative Complications Puberty Retrospective Studies Surgery Survivors Tumors of the nervous system. Phacomatoses |
| title | Growth and endocrine sequelae of craniopharyngioma |
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