Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans. To test this hypothesis, a P1 clone containing the human ABCG5 and ABCG8 genes was used to generate transgenic mice. The transgenes were expr...

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Veröffentlicht in:	The Journal of clinical investigation 2002-09, Vol.110 (5), p.671-680
Hauptverfasser:	Yu, Liqing, Li-Hawkins, Jia, Hammer, Robert E., Berge, Knut E., Horton, Jay D., Cohen, Jonathan C., Hobbs, Helen H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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