Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein. Using mi...

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Veröffentlicht in:	The Journal of clinical investigation 2002-09, Vol.110 (5), p.633-641
Hauptverfasser:	Signoretti, Sabina, Di Marcotullio, Lucia, Richardson, Andrea, Ramaswamy, Sridhar, Isaac, Beth, Rue, Montserrat, Monti, Franco, Loda, Massimo, Pagano, Michele
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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