Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex
The fatty acid compositions of the major cerebral cortex phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were measured in 16 term and one preterm 'cot death' infants fed exclusively either breast milk or one of two formulas. Docosahexaenoic acid (DHA; C...
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Veröffentlicht in: | Archives of disease in childhood 1995-03, Vol.72 (3), p.198-203 |
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description | The fatty acid compositions of the major cerebral cortex phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were measured in 16 term and one preterm 'cot death' infants fed exclusively either breast milk or one of two formulas. Docosahexaenoic acid (DHA; C22:6n-3) content in cerebral cortex phosphatidylethanolamine and phosphatidylserine of breast fed infants was greater than in both formula groups with significances varying between p < 0.1 and p < 0.001. Compensation for this deficiency in DHA in the formula fed infants was largely achieved by increased incorporation of docosapentaenoic acid (C22:5n-6) in the cerebral cortex of term infants and Mead (C20:3n-9) and dihomo Mead acids (C22:3n-9) in the preterm infant. As the phospholipids most affected are known to perform an important role in membrane function and are possibly integral to neurotransmission it is recommended that breast milk substitute infant formulas should contain n-3 and n-6 series polyunsaturated fatty acids in proportions similar to those of human milk. |
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Docosahexaenoic acid (DHA; C22:6n-3) content in cerebral cortex phosphatidylethanolamine and phosphatidylserine of breast fed infants was greater than in both formula groups with significances varying between p < 0.1 and p < 0.001. Compensation for this deficiency in DHA in the formula fed infants was largely achieved by increased incorporation of docosapentaenoic acid (C22:5n-6) in the cerebral cortex of term infants and Mead (C20:3n-9) and dihomo Mead acids (C22:3n-9) in the preterm infant. As the phospholipids most affected are known to perform an important role in membrane function and are possibly integral to neurotransmission it is recommended that breast milk substitute infant formulas should contain n-3 and n-6 series polyunsaturated fatty acids in proportions similar to those of human milk.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.72.3.198</identifier><identifier>PMID: 7741563</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>8,11,14-Eicosatrienoic Acid - analogs & derivatives ; 8,11,14-Eicosatrienoic Acid - metabolism ; Babies ; Biological and medical sciences ; Breast milk ; Breastfeeding & lactation ; Cerebral cortex ; Cerebral Cortex - chemistry ; Development. Senescence. Regeneration. Transplantation ; Diet ; Docosahexaenoic acid ; Docosahexaenoic Acids - chemistry ; Fatty acid composition ; Fatty acids ; Fatty Acids - analysis ; Fatty Acids, Unsaturated - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Infant Food ; Infant formulas ; Infant, Newborn ; Infant, Premature ; Infants ; Lecithin ; Male ; Milk, Human ; Neurotransmission ; Phosphatidylcholine ; Phosphatidylcholines - chemistry ; Phosphatidylethanolamine ; Phosphatidylethanolamines - chemistry ; Phosphatidylserine ; Phosphatidylserines - chemistry ; Phospholipids ; Phospholipids - chemistry ; Polyunsaturated fatty acids ; SIDS ; Sudden Infant Death ; Sudden infant death syndrome ; Vertebrates: nervous system and sense organs ; Young Children</subject><ispartof>Archives of disease in childhood, 1995-03, Vol.72 (3), p.198-203</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Mar 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-2a64ef06c79746a0523cf88a4b6b10e243e142e8ef3b68e6463420fc43d64e813</citedby><cites>FETCH-LOGICAL-b506t-2a64ef06c79746a0523cf88a4b6b10e243e142e8ef3b68e6463420fc43d64e813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511055/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511055/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3445051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7741563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farquharson, J</creatorcontrib><creatorcontrib>Jamieson, E C</creatorcontrib><creatorcontrib>Abbasi, K A</creatorcontrib><creatorcontrib>Patrick, W J</creatorcontrib><creatorcontrib>Logan, R W</creatorcontrib><creatorcontrib>Cockburn, F</creatorcontrib><title>Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>The fatty acid compositions of the major cerebral cortex phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were measured in 16 term and one preterm 'cot death' infants fed exclusively either breast milk or one of two formulas. Docosahexaenoic acid (DHA; C22:6n-3) content in cerebral cortex phosphatidylethanolamine and phosphatidylserine of breast fed infants was greater than in both formula groups with significances varying between p < 0.1 and p < 0.001. Compensation for this deficiency in DHA in the formula fed infants was largely achieved by increased incorporation of docosapentaenoic acid (C22:5n-6) in the cerebral cortex of term infants and Mead (C20:3n-9) and dihomo Mead acids (C22:3n-9) in the preterm infant. As the phospholipids most affected are known to perform an important role in membrane function and are possibly integral to neurotransmission it is recommended that breast milk substitute infant formulas should contain n-3 and n-6 series polyunsaturated fatty acids in proportions similar to those of human milk.</description><subject>8,11,14-Eicosatrienoic Acid - analogs & derivatives</subject><subject>8,11,14-Eicosatrienoic Acid - metabolism</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - chemistry</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Diet</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - chemistry</subject><subject>Fatty acid composition</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Food</subject><subject>Infant formulas</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Lecithin</subject><subject>Male</subject><subject>Milk, Human</subject><subject>Neurotransmission</subject><subject>Phosphatidylcholine</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Phosphatidylethanolamine</subject><subject>Phosphatidylethanolamines - chemistry</subject><subject>Phosphatidylserine</subject><subject>Phosphatidylserines - chemistry</subject><subject>Phospholipids</subject><subject>Phospholipids - chemistry</subject><subject>Polyunsaturated fatty acids</subject><subject>SIDS</subject><subject>Sudden Infant Death</subject><subject>Sudden infant death syndrome</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Children</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUuLFDEUhQtRxnZ051YoUHRjtXkntRGkmVFxUAQfy5BK3dhpqyplkpaZfz8pumnUhYtwF-e7h5N7quoxRmuMqXhleruWZE3XuFV3qhVmQjUEMXa3WiGEaNMqpe5XD1LaIYSJUvSsOpOSYS7oqjIXzoHNdXB176HMqc5bqJ3J-aY21ve1DeMcks--SIVa1NHsQqznbUjlDX72fVokPzkz5dpChC6aoWzGDNcPq3vODAkeHed59fXy4svmXXP16e37zZurpuNI5IYYwcAhYWUrmTCIE2qdUoZ1osMICKOAGQEFjnZCgWCCMoKcZbQviwrT8-r1wXfedyP0FqZcQug5-tHEGx2M138rk9_qH-G3xhxjxHkxeH40iOHXHlLWo08WhsFMEPZJS0l4K2hbwKf_gLuwj1P5nKaoxG8xV6xQLw-UjSGlCO4UBSO9FKdLcVoSTXUpruBP_ox_go9NFf3ZUTfJmsFFM1mfThhljCO-XKE5YD6V259kE39qIank-uO3jWYfvn_mLb_Ui-2LA9-Nu_8HvAVrmrx6</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>Farquharson, J</creator><creator>Jamieson, E C</creator><creator>Abbasi, K A</creator><creator>Patrick, W J</creator><creator>Logan, R W</creator><creator>Cockburn, F</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19950301</creationdate><title>Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex</title><author>Farquharson, J ; Jamieson, E C ; Abbasi, K A ; Patrick, W J ; Logan, R W ; Cockburn, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-2a64ef06c79746a0523cf88a4b6b10e243e142e8ef3b68e6463420fc43d64e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>8,11,14-Eicosatrienoic Acid - analogs & derivatives</topic><topic>8,11,14-Eicosatrienoic Acid - metabolism</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - chemistry</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Diet</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - chemistry</topic><topic>Fatty acid composition</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food</topic><topic>Infant formulas</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Lecithin</topic><topic>Male</topic><topic>Milk, Human</topic><topic>Neurotransmission</topic><topic>Phosphatidylcholine</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Phosphatidylethanolamine</topic><topic>Phosphatidylethanolamines - chemistry</topic><topic>Phosphatidylserine</topic><topic>Phosphatidylserines - chemistry</topic><topic>Phospholipids</topic><topic>Phospholipids - chemistry</topic><topic>Polyunsaturated fatty acids</topic><topic>SIDS</topic><topic>Sudden Infant Death</topic><topic>Sudden infant death syndrome</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farquharson, J</creatorcontrib><creatorcontrib>Jamieson, E C</creatorcontrib><creatorcontrib>Abbasi, K A</creatorcontrib><creatorcontrib>Patrick, W J</creatorcontrib><creatorcontrib>Logan, R W</creatorcontrib><creatorcontrib>Cockburn, F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farquharson, J</au><au>Jamieson, E C</au><au>Abbasi, K A</au><au>Patrick, W J</au><au>Logan, R W</au><au>Cockburn, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>72</volume><issue>3</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>The fatty acid compositions of the major cerebral cortex phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were measured in 16 term and one preterm 'cot death' infants fed exclusively either breast milk or one of two formulas. Docosahexaenoic acid (DHA; C22:6n-3) content in cerebral cortex phosphatidylethanolamine and phosphatidylserine of breast fed infants was greater than in both formula groups with significances varying between p < 0.1 and p < 0.001. Compensation for this deficiency in DHA in the formula fed infants was largely achieved by increased incorporation of docosapentaenoic acid (C22:5n-6) in the cerebral cortex of term infants and Mead (C20:3n-9) and dihomo Mead acids (C22:3n-9) in the preterm infant. As the phospholipids most affected are known to perform an important role in membrane function and are possibly integral to neurotransmission it is recommended that breast milk substitute infant formulas should contain n-3 and n-6 series polyunsaturated fatty acids in proportions similar to those of human milk.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>7741563</pmid><doi>10.1136/adc.72.3.198</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism Babies Biological and medical sciences Breast milk Breastfeeding & lactation Cerebral cortex Cerebral Cortex - chemistry Development. Senescence. Regeneration. Transplantation Diet Docosahexaenoic acid Docosahexaenoic Acids - chemistry Fatty acid composition Fatty acids Fatty Acids - analysis Fatty Acids, Unsaturated - metabolism Female Fundamental and applied biological sciences. Psychology Humans Infant Infant Food Infant formulas Infant, Newborn Infant, Premature Infants Lecithin Male Milk, Human Neurotransmission Phosphatidylcholine Phosphatidylcholines - chemistry Phosphatidylethanolamine Phosphatidylethanolamines - chemistry Phosphatidylserine Phosphatidylserines - chemistry Phospholipids Phospholipids - chemistry Polyunsaturated fatty acids SIDS Sudden Infant Death Sudden infant death syndrome Vertebrates: nervous system and sense organs Young Children |
title | Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex |
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