Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease
Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increa...
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| Veröffentlicht in: | Archives of disease in childhood 1995-03, Vol.72 (3), p.227-229 |
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| creator | Singhal, A Thomas, P Kearney, T Venugopal, S Serjeant, G |
| description | Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increases in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS. |
| doi_str_mv | 10.1136/adc.72.3.227 |
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Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increases in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.72.3.227</identifier><identifier>PMID: 7741569</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Anemias. Hemoglobinopathies ; Biological and medical sciences ; Body Height ; Body Weight ; Child ; Child, Preschool ; Dietary supplements ; Diseases of red blood cells ; Dysentery ; Erythrocyte Indices ; Female ; Growth ; Hematologic and hematopoietic diseases ; Hematologic Tests ; Humans ; Hypersplenism ; Hypersplenism - blood ; Hypersplenism - physiopathology ; Hypersplenism - surgery ; Infant ; Male ; Medical sciences ; Nutrient deficiency ; Pediatrics ; Sickle cell disease ; Sickle Cell Trait - blood ; Sickle Cell Trait - complications ; Sickle Cell Trait - physiopathology ; Sickle Cell Trait - surgery ; Splenectomy ; Velocity ; Waterborne diseases</subject><ispartof>Archives of disease in childhood, 1995-03, Vol.72 (3), p.227-229</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Mar 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-3ce8718e7772b03d0150f70ebfff18882cc1bbed5b03a5a32be585b79e9be7d3</citedby><cites>FETCH-LOGICAL-b506t-3ce8718e7772b03d0150f70ebfff18882cc1bbed5b03a5a32be585b79e9be7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511050/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511050/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3445057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7741569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singhal, A</creatorcontrib><creatorcontrib>Thomas, P</creatorcontrib><creatorcontrib>Kearney, T</creatorcontrib><creatorcontrib>Venugopal, S</creatorcontrib><creatorcontrib>Serjeant, G</creatorcontrib><title>Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increases in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS.</description><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dietary supplements</subject><subject>Diseases of red blood cells</subject><subject>Dysentery</subject><subject>Erythrocyte Indices</subject><subject>Female</subject><subject>Growth</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematologic Tests</subject><subject>Humans</subject><subject>Hypersplenism</subject><subject>Hypersplenism - blood</subject><subject>Hypersplenism - physiopathology</subject><subject>Hypersplenism - surgery</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nutrient deficiency</subject><subject>Pediatrics</subject><subject>Sickle cell disease</subject><subject>Sickle Cell Trait - blood</subject><subject>Sickle Cell Trait - complications</subject><subject>Sickle Cell Trait - physiopathology</subject><subject>Sickle Cell Trait - surgery</subject><subject>Splenectomy</subject><subject>Velocity</subject><subject>Waterborne diseases</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1vEzEYhC1EVULhxhXJEoheusEf67X3glRFNEWt4FLB0bK97yZOd9epvQHCr8dpogg4cLLked7RjAahV5RMKeXVe9O4qWRTPmVMPkETWlaqYKQsn6IJIYQXtVLqGXqe0ooQypTip-hUypKKqp4gd-kcdBDN6MOA_YA7P4CJeBHDj3GJTTtCxGndwQBuDP0WtyHi5XYN8fHTp353tAx9-LVdhE3Cybv7DnA27XDjE5gEL9BJa7oELw_vGbq7-ng3uy5uv8w_zS5vCytINRbcgZJUgZSSWcIbQgVpJQHbti3NHZhz1FpoRBaNMJxZEEpYWUNtQTb8DH3Y2643tofGwTBG0-l19L2JWx2M138rg1_qRfiuqaCUCJIN3h0MYnjYQBp179OuiBkgV9M5VyUV5Rl88w-4Cps45G6aE1krwkpWZupiT7kYUorQHqNQonfL6byclkxznZfL-Os_4x_hw1RZf3vQTXKma6MZnE9HjJelIGJnU-wxn0b4eZRNvNeV5FLoz19nur6-md_wb1d6nvnzPW_71f8D_gaoq793</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>Singhal, A</creator><creator>Thomas, P</creator><creator>Kearney, T</creator><creator>Venugopal, S</creator><creator>Serjeant, G</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19950301</creationdate><title>Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease</title><author>Singhal, A ; Thomas, P ; Kearney, T ; Venugopal, S ; Serjeant, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-3ce8718e7772b03d0150f70ebfff18882cc1bbed5b03a5a32be585b79e9be7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dietary supplements</topic><topic>Diseases of red blood cells</topic><topic>Dysentery</topic><topic>Erythrocyte Indices</topic><topic>Female</topic><topic>Growth</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematologic Tests</topic><topic>Humans</topic><topic>Hypersplenism</topic><topic>Hypersplenism - blood</topic><topic>Hypersplenism - physiopathology</topic><topic>Hypersplenism - surgery</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nutrient deficiency</topic><topic>Pediatrics</topic><topic>Sickle cell disease</topic><topic>Sickle Cell Trait - blood</topic><topic>Sickle Cell Trait - complications</topic><topic>Sickle Cell Trait - physiopathology</topic><topic>Sickle Cell Trait - surgery</topic><topic>Splenectomy</topic><topic>Velocity</topic><topic>Waterborne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singhal, A</creatorcontrib><creatorcontrib>Thomas, P</creatorcontrib><creatorcontrib>Kearney, T</creatorcontrib><creatorcontrib>Venugopal, S</creatorcontrib><creatorcontrib>Serjeant, G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singhal, A</au><au>Thomas, P</au><au>Kearney, T</au><au>Venugopal, S</au><au>Serjeant, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>72</volume><issue>3</issue><spage>227</spage><epage>229</epage><pages>227-229</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increases in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>7741569</pmid><doi>10.1136/adc.72.3.227</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anemias. Hemoglobinopathies Biological and medical sciences Body Height Body Weight Child Child, Preschool Dietary supplements Diseases of red blood cells Dysentery Erythrocyte Indices Female Growth Hematologic and hematopoietic diseases Hematologic Tests Humans Hypersplenism Hypersplenism - blood Hypersplenism - physiopathology Hypersplenism - surgery Infant Male Medical sciences Nutrient deficiency Pediatrics Sickle cell disease Sickle Cell Trait - blood Sickle Cell Trait - complications Sickle Cell Trait - physiopathology Sickle Cell Trait - surgery Splenectomy Velocity Waterborne diseases |
| title | Acceleration in linear growth after splenectomy for hypersplenism in homozygous sickle cell disease |
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