A pharmacological profile of the novel, peripherally-selective κ-opioid receptor agonist, EMD 61753

1. The pharmacological properties of the novel diarylacetamide kappa-opioid receptor agonist, EMD 61753, have been compared with those of ICI 197067 (a centrally-acting kappa agonist) and ICI 204448 (a peripherally-selective kappa agonist). 2. EMD 61753 binds with high affinity (IC50 5.6 nM) and sel...

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Veröffentlicht in:	British journal of pharmacology 1994-12, Vol.113 (4), p.1317-1327
Hauptverfasser:	BARBER, A, BARTOSZYK, G. D, SEYFRIED, C. A, BENDER, H. M, GOTTSCHLICH, R, GREINER, H. E, HARTING, J, MAULER, F, MINCK, K.-O, MURRAY, R. D, SIMON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - antagonists & inhibitors Acetamides - pharmacokinetics Acetamides - pharmacology Adrenergic alpha-Agonists - pharmacokinetics Adrenergic alpha-Agonists - pharmacology Analgesics - antagonists & inhibitors Analgesics - pharmacology Animals Autoradiography Biological and medical sciences Blood-Brain Barrier - drug effects Capillary Permeability - drug effects Dihydroxyphenylalanine - metabolism Diuresis - drug effects Haloperidol - antagonists & inhibitors Haloperidol - pharmacology Hexobarbital - pharmacology Male Medical sciences Mice Narcotics - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pain Measurement - drug effects Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Peripheral Nervous System - drug effects Pharmacology. Drug treatments Postural Balance - drug effects Prostaglandin Antagonists - pharmacology Pyrrolidines - antagonists & inhibitors Pyrrolidines - pharmacokinetics Pyrrolidines - pharmacology Rats Rats, Wistar Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism
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