Interactions of chloroethylclonidine with rauwolscine‐ and prazosin‐sensitive adrenoceptors in dog saphenous vein

1 α1‐Adrenoceptors have been classified pharmacologically into four subtypes (α1A, α1B, â1c and α1D) on the basis of their differential affinity for novel antagonists such as chloroethylclonidine (CEC). While CEC is considered an α1B‐adrenoceptor antagonist, our earlier studies revealed that it also...

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Veröffentlicht in:	British journal of pharmacology 1994-12, Vol.113 (4), p.1263-1268
Hauptverfasser:	Low, A.M., Bowdish, D.M., Prashad, T.R., Gaspar, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists Adrenergic beta-Antagonists - pharmacology Animals Ca2+ entry Ca2+ release Calcium - metabolism Calcium Channel Blockers - pharmacology Clonidine - analogs & derivatives Clonidine - pharmacology Dioxanes - pharmacology Dogs Extracellular Space - drug effects Extracellular Space - metabolism genistein In Vitro Techniques Membranes - drug effects Membranes - metabolism Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Prazosin - pharmacology radioligand binding Saphenous Vein - drug effects Saphenous Vein - metabolism SK&F 96365 Vascular Yohimbine - pharmacology
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