Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1

Corepressors N‐CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC3, TBL1 and TBLR1. However, the roles of these proteins in SMRT–N‐CoR complex function are largely unknown. Here we report the purification and functional characterization of the...

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Veröffentlicht in:	The EMBO journal 2003-03, Vol.22 (6), p.1336-1346
Hauptverfasser:	Yoon, Ho-Geun, Chan, Doug W., Huang, Zhi-Qing, Li, Jiwen, Fondell, Joseph D., Qin, Jun, Wong, Jiemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line DNA-Binding Proteins - chemistry DNA-Binding Proteins - isolation & purification EMBO09 HDAC3 HeLa Cells Histone Deacetylases - chemistry Histone Deacetylases - metabolism histone interaction Histones - metabolism Humans Microfilament Proteins - chemistry N-CoR Nuclear Proteins - chemistry Nuclear Proteins - isolation & purification Nuclear Proteins - metabolism Peptide Fragments - chemistry Peptide Fragments - immunology Protein Binding Protein Structure, Tertiary Protein Subunits Receptors, Cytoplasmic and Nuclear Receptors, Thyroid Hormone - metabolism Recombinant Proteins - metabolism Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - isolation & purification Repressor Proteins - metabolism RNA, Small Interfering - metabolism Sequence Homology, Amino Acid TBL1 TBLR1 Thyroid Transducin - chemistry Transducin - metabolism
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