Respiratory effects of baclofen and 3‐aminopropylphosphinic acid in guinea‐pigs

1 The effects of the GABAB receptor agonists, baclofen and 3‐aminopropylphosphinic acid (3‐APPi) given by the subcutaneous or intracerebroventricular (i.c.v.) route were examined on minute ventilation (), tidal volume (VT) and respiratory rate (f) due to room air and carbon dioxide (CO2)‐enriched ga...

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Veröffentlicht in:	British journal of pharmacology 1995-02, Vol.114 (4), p.735-738
Hauptverfasser:	Hey, John A., Mingo, Garfield, Bolser, Donald C., Kreutner, William, Krobatsch, Dawn, Chapman, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐aminopropylphosphinic acid Administration, Inhalation Analysis of Variance Animals baclofen Baclofen - administration & dosage Baclofen - pharmacology Bicuculline - administration & dosage Bicuculline - pharmacology Biological and medical sciences Carbon Dioxide - metabolism CNS Dose-Response Relationship, Drug Drug Interactions GABA Agonists - administration & dosage GABA Agonists - pharmacology GABA-A Receptor Antagonists GABA-B Receptor Antagonists GABAB receptors Guinea Pigs Injections, Intraventricular Injections, Subcutaneous Male Medical sciences minute volume Naloxone - administration & dosage Naloxone - pharmacology Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments Pulmonary Ventilation - drug effects respiration Respiration - drug effects Respiratory system Tidal Volume - drug effects
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