Improvement in glucose tolerance due to Momordica charantia (karela)
The effect of karela (Momordica charantia), a fruit indigenous to South America and Asia, on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic laboratory rats. A water-soluble extract of the fruits significantly reduced blood glucose concentr...
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| Veröffentlicht in: | BMJ 1981-06, Vol.282 (6279), p.1823-1824 |
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| container_issue | 6279 |
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| creator | Leatherdale, B A Panesar, R K Singh, G Atkins, T W Bailey, C J Bignell, A H |
| description | The effect of karela (Momordica charantia), a fruit indigenous to South America and Asia, on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic laboratory rats. A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the rats. Fried karela fruits consumed as a daily supplement to the diet produced a small but significant improvement in glucose tolerance. Improvement in glucose tolerance was not associated with an increase in serum insulin responses. These results show that karela improves glucose tolerance in diabetes. Doctors supervising Asian diabetics should be aware of the fruit's hypoglycaemic properties. |
| doi_str_mv | 10.1136/bmj.282.6279.1823 |
| format | Article |
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A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the rats. Fried karela fruits consumed as a daily supplement to the diet produced a small but significant improvement in glucose tolerance. Improvement in glucose tolerance was not associated with an increase in serum insulin responses. These results show that karela improves glucose tolerance in diabetes. 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A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the rats. Fried karela fruits consumed as a daily supplement to the diet produced a small but significant improvement in glucose tolerance. Improvement in glucose tolerance was not associated with an increase in serum insulin responses. These results show that karela improves glucose tolerance in diabetes. Doctors supervising Asian diabetics should be aware of the fruit's hypoglycaemic properties.</description><subject>Animals</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Clinical Research</subject><subject>Diabetes</subject><subject>Diabetes complications</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diet therapy</subject><subject>Diet</subject><subject>Female</subject><subject>Fruit</subject><subject>Fruits</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Juices</subject><subject>Male</subject><subject>Rats</subject><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkd1r1EAUxQex1KXtH-CDEBBEwazzkbkz81KQrbbFVhGrr8NNMmmzTTLrTFL0v3fCLuvHi0-Xy-_cw7kcQp4yumRMwJuyXy-55kvgyiyZ5uIRWbACdC61EI_JgnJQOQUunpCTGNeUUi6UNlAckkNQGkDIBTm77DfBP7jeDWPWDtltN1U-umz0nQs4VC6rp3nLrn3vQ91WmFV3mMjYYvbyHoPr8NUxOWiwi-5kN4_I1_fvblYX-dWn88vV26u8lMyMeWOQ6Zo5XsvKFCplUJKiEQVFXZYFNGWajeQIggIUGjnqQiIrmVOKp5-PyOnWdzOVvaurlDlgZzeh7TH8tB5b-zcZ2jt76x8skxSEUcngxc4g-O-Ti6Pt21i5rsPB-SlaJUFyY3gSPv9HuPZTGNJzlikFAjSw2Y5tVVXwMQbX7KMwaueObOrIpo7s3JGdO0o3z_78YX-xa-Q3X8fRhz3mRlLOYeb5lrdxdD_2HMN9shBK2o_fVlaaM7j-_OGLvUn611v9HOX_8X4B7hSy2A</recordid><startdate>19810606</startdate><enddate>19810606</enddate><creator>Leatherdale, B A</creator><creator>Panesar, R K</creator><creator>Singh, G</creator><creator>Atkins, T W</creator><creator>Bailey, C J</creator><creator>Bignell, A H</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810606</creationdate><title>Improvement in glucose tolerance due to Momordica charantia (karela)</title><author>Leatherdale, B A ; 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| ispartof | BMJ, 1981-06, Vol.282 (6279), p.1823-1824 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Animals Blood Blood Glucose - metabolism Clinical Research Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - diet therapy Diet Female Fruit Fruits Glucose tolerance Glucose Tolerance Test Humans Insulin Insulin - blood Juices Male Rats |
| title | Improvement in glucose tolerance due to Momordica charantia (karela) |
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