Bone Morphogenetic Proteins 2, 4, and 9 Stimulate Murine Hepcidin 1 Expression Independently of Hfe, Transferrin Receptor 2 (Tfr2), and IL-6

Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4. We investigate the role of Hfe, Tfr2 (transferrin receptor 2), and IL-6 i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-07, Vol.103 (27), p.10289-10293
Hauptverfasser:	Truksa, Jaroslav, Peng, Hongfan, Lee, Pauline, Beutler, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism Biological Sciences Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - pharmacology Bones Cells, Cultured Complementary DNA Growth Differentiation Factor 2 Growth Differentiation Factors Hemochromatosis Protein Hep G2 cells Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepcidins Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Interleukin-6 - deficiency Interleukin-6 - genetics Interleukin-6 - metabolism Iron Lipopolysaccharides - pharmacology Liver Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Messenger RNA Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics Peptides Proteins Receptors Receptors, Transferrin - deficiency Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Reverse transcriptase polymerase chain reaction Ribosomal proteins Transfer RNA Transforming Growth Factor beta - pharmacology Up regulation Up-Regulation - drug effects
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