Calcium-dependent release of NO from intracellular S-nitrosothiols

The paper describes a novel cellular mechanism for rapid calcium‐dependent nitric oxide (NO) release. This release occurs due to NO liberation from S ‐nitrosothiols. We have analysed the changes of NO concentration in acutely isolated pancreatic acinar cells. Supramaximal acetylcholine (ACh) stimula...

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Veröffentlicht in:	The EMBO journal 2006-07, Vol.25 (13), p.3024-3032
Hauptverfasser:	Chvanov, Michael, Gerasimenko, Oleg V, Petersen, Ole H, Tepikin, Alexei V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Acrylates - pharmacology Animals Biochemistry Calcium Calcium - physiology Calmodulin - antagonists & inhibitors Calmodulin - metabolism Calpain - antagonists & inhibitors Calpain - metabolism Cells, Cultured EMBO37 Fluoresceins Fluorescence Fluorescent Dyes glutathione Glutathione - metabolism Intracellular Space - metabolism Male Mice Neurons - cytology Neurons - physiology Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism NOS Pancreas Pancreas - cytology Physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism S-nitrosothiols S-Nitrosothiols - metabolism Signal transduction
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