Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C

Macropinocytosis results from the closure of lamellipodia generated by membrane ruffling, thereby reflecting cortical actin dynamics. Both transformation of Rat-1 fibroblasts by v-Src or K-Ras and stable transfection for expression of dominant-positive, wild-type phosphoinositide 3-kinase (PI3K) reg...

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Veröffentlicht in:	Molecular biology of the cell 2000-10, Vol.11 (10), p.3453-3467
Hauptverfasser:	Amyere, M, Payrastre, B, Krause, U, Van Der Smissen, P, Veithen, A, Courtoy, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Sarcoma Viruses - genetics Cattle Cell Line Cell Transformation, Neoplastic Enzyme Activation Genes, src Genetic Vectors Horseradish Peroxidase - pharmacokinetics Kinetics Microscopy, Electron, Scanning Organelles - physiology Organelles - ultrastructure Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pinocytosis - physiology Protein Subunits Rats Recombinant Proteins - metabolism Sequence Deletion Transfection Type C Phospholipases - metabolism
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