High-dose photoirradiation of esophageal cancer
Fifteen patients with locally advanced esophageal cancer were treated with phototherapy. Each patient had dysphagia and weight loss before therapy and could not be operated on because of the extent of the tumor or poor performance status. Patients received a photosensitizer (hematoporphyrin derivati...
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| Veröffentlicht in: | Annals of surgery 1987-08, Vol.206 (2), p.193-199 |
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| container_issue | 2 |
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| container_title | Annals of surgery |
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| creator | THOMAS, R. J ABBOTT, M BHATHAL, P. S ST. JOHN, D. J. B MORSTYN, G |
| description | Fifteen patients with locally advanced esophageal cancer were treated with phototherapy. Each patient had dysphagia and weight loss before therapy and could not be operated on because of the extent of the tumor or poor performance status. Patients received a photosensitizer (hematoporphyrin derivative) 72 hours before phototherapy and were then treated by light delivered by an argon pumped dye laser or gold metal vapor laser at powers up to 2.2 W and doses of 337 J/cm2. Fourteen patients received 24 treatments. The results were all patients achieved a tumor response. The depth of response depended on the dose and dose rate of radiation. There were four of 24 local complications (mediastinitis 3, bronchoesophageal fistula 1). These occurred in patients treated with a power of greater than 1.5 W. There were two complete pathologic remissions in patients with locally advanced cancer. In conclusion, phototherapy is an effective alternative to other forms of palliation and potentially may be an alternative to surgery in selected cases of locally advanced esophageal cancer. |
| doi_str_mv | 10.1097/00000658-198708000-00012 |
| format | Article |
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J ; ABBOTT, M ; BHATHAL, P. S ; ST. JOHN, D. J. B ; MORSTYN, G</creator><creatorcontrib>THOMAS, R. J ; ABBOTT, M ; BHATHAL, P. S ; ST. JOHN, D. J. B ; MORSTYN, G</creatorcontrib><description>Fifteen patients with locally advanced esophageal cancer were treated with phototherapy. Each patient had dysphagia and weight loss before therapy and could not be operated on because of the extent of the tumor or poor performance status. Patients received a photosensitizer (hematoporphyrin derivative) 72 hours before phototherapy and were then treated by light delivered by an argon pumped dye laser or gold metal vapor laser at powers up to 2.2 W and doses of 337 J/cm2. Fourteen patients received 24 treatments. The results were all patients achieved a tumor response. The depth of response depended on the dose and dose rate of radiation. There were four of 24 local complications (mediastinitis 3, bronchoesophageal fistula 1). These occurred in patients treated with a power of greater than 1.5 W. There were two complete pathologic remissions in patients with locally advanced cancer. In conclusion, phototherapy is an effective alternative to other forms of palliation and potentially may be an alternative to surgery in selected cases of locally advanced esophageal cancer.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-198708000-00012</identifier><identifier>PMID: 3606245</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adenocarcinoma - drug therapy ; Aged ; Biological and medical sciences ; Carcinoma, Squamous Cell - drug therapy ; Esophageal Neoplasms - drug therapy ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Photochemotherapy ; Tumors</subject><ispartof>Annals of surgery, 1987-08, Vol.206 (2), p.193-199</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-74ec1c67f30327af5eef5775170fd55eb88b4f7df8140f1f5479c4ece217b0783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1493120/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1493120/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7437052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3606245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMAS, R. J</creatorcontrib><creatorcontrib>ABBOTT, M</creatorcontrib><creatorcontrib>BHATHAL, P. S</creatorcontrib><creatorcontrib>ST. JOHN, D. J. B</creatorcontrib><creatorcontrib>MORSTYN, G</creatorcontrib><title>High-dose photoirradiation of esophageal cancer</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>Fifteen patients with locally advanced esophageal cancer were treated with phototherapy. Each patient had dysphagia and weight loss before therapy and could not be operated on because of the extent of the tumor or poor performance status. Patients received a photosensitizer (hematoporphyrin derivative) 72 hours before phototherapy and were then treated by light delivered by an argon pumped dye laser or gold metal vapor laser at powers up to 2.2 W and doses of 337 J/cm2. Fourteen patients received 24 treatments. The results were all patients achieved a tumor response. The depth of response depended on the dose and dose rate of radiation. There were four of 24 local complications (mediastinitis 3, bronchoesophageal fistula 1). These occurred in patients treated with a power of greater than 1.5 W. There were two complete pathologic remissions in patients with locally advanced cancer. In conclusion, phototherapy is an effective alternative to other forms of palliation and potentially may be an alternative to surgery in selected cases of locally advanced esophageal cancer.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photochemotherapy</subject><subject>Tumors</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF9LwzAUxYMoc04_gtAH8a0uf5v0RZChThj4os8hTZM10jU16QS_vZnWooEQcs85Nzc_ADIEbxAs-RIeVsFEjkrBoUiXPG2Ej8AcMZzKiMJjME81ktOS4FNwFuNbclAB-QzMSAELTNkcLNdu2-S1jybrGz94F4KqnRqc7zJvMxN936itUW2mVadNOAcnVrXRXIznArw-3L-s1vnm-fFpdbfJNaV0yDk1GumCWwIJ5soyYyzjnCEObc2YqYSoqOW1FWlQiyyjvNQpYzDiFeSCLMDtT99-X-1MrU03BNXKPridCp_SKyf_K51r5NZ_SJS-izBMDa7HBsG_700c5M5FbdpWdcbvo-S8oAkdS0bxY9TBxxiMnR5BUB5gy1_YcoItv2Gn6OXfIafgSDfpV6OuolatDQmhi5ONU5IGwOQLCSGHKA</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>THOMAS, R. J</creator><creator>ABBOTT, M</creator><creator>BHATHAL, P. S</creator><creator>ST. 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B ; MORSTYN, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-74ec1c67f30327af5eef5775170fd55eb88b4f7df8140f1f5479c4ece217b0783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Photochemotherapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, R. J</creatorcontrib><creatorcontrib>ABBOTT, M</creatorcontrib><creatorcontrib>BHATHAL, P. S</creatorcontrib><creatorcontrib>ST. JOHN, D. J. B</creatorcontrib><creatorcontrib>MORSTYN, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMAS, R. J</au><au>ABBOTT, M</au><au>BHATHAL, P. S</au><au>ST. JOHN, D. J. B</au><au>MORSTYN, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-dose photoirradiation of esophageal cancer</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>206</volume><issue>2</issue><spage>193</spage><epage>199</epage><pages>193-199</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>Fifteen patients with locally advanced esophageal cancer were treated with phototherapy. Each patient had dysphagia and weight loss before therapy and could not be operated on because of the extent of the tumor or poor performance status. Patients received a photosensitizer (hematoporphyrin derivative) 72 hours before phototherapy and were then treated by light delivered by an argon pumped dye laser or gold metal vapor laser at powers up to 2.2 W and doses of 337 J/cm2. Fourteen patients received 24 treatments. The results were all patients achieved a tumor response. The depth of response depended on the dose and dose rate of radiation. There were four of 24 local complications (mediastinitis 3, bronchoesophageal fistula 1). These occurred in patients treated with a power of greater than 1.5 W. There were two complete pathologic remissions in patients with locally advanced cancer. In conclusion, phototherapy is an effective alternative to other forms of palliation and potentially may be an alternative to surgery in selected cases of locally advanced esophageal cancer.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>3606245</pmid><doi>10.1097/00000658-198708000-00012</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of surgery, 1987-08, Vol.206 (2), p.193-199 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adenocarcinoma - drug therapy Aged Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Esophageal Neoplasms - drug therapy Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Photochemotherapy Tumors |
| title | High-dose photoirradiation of esophageal cancer |
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