The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

The transcriptional coactivator OBF‐1, which interacts with Oct‐1 and Oct‐2 and the octamer site DNA, has been shown to be critical for development of a normal immune response and the formation of germinal centers in secondary lymphoid organs. Here we have identified the RING finger protein Siah‐1 a...

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Veröffentlicht in:	The EMBO journal 2001-08, Vol.20 (15), p.4143-4152
Hauptverfasser:	Tiedt, Ralph, Bartholdy, Boris A., Matthias, Gabriele, Newell, John W., Matthias, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals B cell transcription B-Lymphocytes - cytology B-Lymphocytes - metabolism Binding Sites Boronic Acids - pharmacology Cell Line Cell Line, Transformed Cysteine Endopeptidases Cysteine Proteinase Inhibitors - pharmacology Deoxyribonucleic acid DNA Down-Regulation Humans Immune response Immunization Mice Molecular Sequence Data Multienzyme Complexes Nuclear Proteins - genetics Nuclear Proteins - metabolism OBF-1 OBF-1 protein Proteasome Endopeptidase Complex RING finger proteins RNA Processing, Post-Transcriptional Siah-1 protein Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation ubiquitin-proteasome pathway Ubiquitin-Protein Ligases Ubiquitins - metabolism Up-Regulation Zinc Fingers
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