The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans

We have recently shown that the leukotriene B4 (LTB4)–BLT1 pathway is important in early effector T-cell recruitment in mouse models of inflammation. Here we characterize the phenotype and function of human peripheral blood BLT1+ T cells in health and illustrate their involvement in asthma and acute...

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Veröffentlicht in:	Blood 2006-01, Vol.107 (2), p.444-453
Hauptverfasser:	Islam, Sabina A., Thomas, Seddon Y., Hess, Christoph, Medoff, Benjamin D., Means, Terry K., Brander, Christian, Lilly, Craig M., Tager, Andrew M., Luster, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease ADP-ribosyl Cyclase 1 - immunology ADP-ribosyl Cyclase 1 - metabolism Asthma - immunology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Case-Control Studies Cells, Cultured Chemokines, Cytokines, and Interleukins Epstein-Barr Virus Infections - immunology Epstein-Barr Virus Infections - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Herpesvirus 4, Human - isolation & purification HLA-DR Antigens - immunology HLA-DR Antigens - metabolism Humans Immunobiology Inflammation Interferon-gamma - metabolism Interleukin-4 - metabolism Leukotriene B4 - metabolism Lymphocyte Activation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Protein-Serine-Threonine Kinases - metabolism Receptors, CCR2 Receptors, CCR6 Receptors, Chemokine - metabolism Receptors, Interleukin-8A - metabolism Receptors, Leukotriene B4 - genetics Receptors, Leukotriene B4 - immunology Receptors, Leukotriene B4 - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - immunology Receptors, Purinergic P2 - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
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