Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18

Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18⁻/⁻ mice compared to wild-type mice and in IL-12p40⁻/⁻ compared to IL...

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Veröffentlicht in:	Infection and Immunity 2006-07, Vol.74 (7), p.4370-4374
Hauptverfasser:	Murray, Henry W, Tsai, Christine W, Liu, Jianguo, Ma, Xiaojing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Genetic Predisposition to Disease Immunity, Innate - genetics Interferon-gamma - biosynthesis Interleukin-12 - deficiency Interleukin-12 - genetics Interleukin-18 - deficiency Interleukin-18 - genetics Interleukin-23 Interleukin-23 Subunit p19 Interleukins - deficiency Interleukins - genetics Leishmania donovani Leishmania donovani - immunology Leishmaniasis, Visceral - genetics Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microbiology
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Zusammenfassung:	Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18⁻/⁻ mice compared to wild-type mice and in IL-12p40⁻/⁻ compared to IL-12p35⁻/⁻ mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00422-06