Multiple-turnover thio-ATP hydrolase and phospho-enzyme intermediate formation activities catalyzed by an RNA enzyme

Ribozymes that phosphorylate internal 2′-OH positions mimic the first mechanistic step of P-type ATPase enzymes by forming a phospho-enzyme intermediate. We previously described 2′-autophosphorylation and autothiophosphorylation by the 2PTmin3.2 ribozyme. In the present work we demonstrate that the...

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Veröffentlicht in:	Nucleic acids research 2006-01, Vol.34 (11), p.3201-3208
Hauptverfasser:	Saran, Dayal, Held, Daniel M., Burke, Donald H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Catalysis Hydrogen-Ion Concentration Hydrolases - chemistry Hydrolases - metabolism Metals - chemistry Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - metabolism RNA, Catalytic - chemistry RNA, Catalytic - metabolism Temperature
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