Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA

The protein O6-alkylguanine-DNA alkyltransferase (alkyltransferase) is involved in the repair of O6-alkylguanine and O4-alkylthymine in DNA and plays an important role in most organisms in attenuating the cytotoxic and mutagenic effects of certain classes of alkylating agents. A genomic clone encomp...

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Veröffentlicht in:	Nucleic acids research 1999-04, Vol.27 (8), p.1795-1801
Hauptverfasser:	Kooistra, Rolf, Zonneveld, José B.M., Lohman, Paul H.M., Pastink, Albert, Watson, Amanda J., Margison, Geoffrey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Proteins - genetics Base Sequence Cloning, Molecular DNA Repair DNA, Complementary Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli Proteins Gene Deletion Guanine - analogs & derivatives Guanine - metabolism Guanine - pharmacology Humans Methylnitronitrosoguanidine Methyltransferases Molecular Sequence Data O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism Phenotype Thymine - analogs & derivatives Thymine - metabolism Transcription Factors
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