Heat shock of HeLa cells inactivates a nuclear protein phosphatase specific for dephosphorylation of the C-terminal domain of RNA polymerase II

Reversible phosphorylation of the C-terminal domain (CTD) of the largest RNA polymerase II (RNAP II) subunit plays a key role in gene expression. Stresses such as heat shock result in marked changes in CTD phosphorylation as well as in major alterations in gene expression. CTD kinases and CTD phosph...

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Veröffentlicht in:	Nucleic acids research 1999-03, Vol.27 (5), p.1338-1344
Hauptverfasser:	Dubois, Marie-Françoise, Nguyen, Van Trung, Bonnet, François, Bensaude, Olivier, Marshall, Nick F., Dahmus, Grace K., Dahmus, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Nucleus - enzymology Fluorescent Antibody Technique Heat-Shock Response HeLa Cells Humans Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - metabolism Phosphorylation RNA Polymerase II - chemistry RNA Polymerase II - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transcription Factors, TFII
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