DNA Diffusion in Mucus: Effect of Size, Topology of DNAs, and Transfection Reagents

DNA represents a promising therapeutic and prophylactic macromolecule in treating genetic diseases, infectious diseases and cancers. The therapeutic potential of DNA is directly related to how DNA transports within the targeted tissue. In this study, fluorescence photobleaching recovery was used to...

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Veröffentlicht in:	Biophysical journal 2006-07, Vol.91 (2), p.639-644
Hauptverfasser:	Shen, Hong, Hu, Yueyue, Saltzman, W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Body fluids Cattle Deoxyribonucleic acid Diffusion DNA DNA, Circular - physiology DNA, Superhelical - physiology Gels - chemistry Liposomes - chemistry Molecules Mucus - physiology Nucleic Acids Plasmids - physiology Polymers - chemistry Transfection
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