Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly

The adenovirus early region 4 ORF4 protein (E4orf4) triggers a novel death program that bypasses classical apoptotic pathways in human cancer cells. Deregulation of the cell cytoskeleton is a hallmark of E4orf4 killing that relies on Src family kinases and E4orf4 phosphorylation. However, the cytosk...

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Veröffentlicht in:	Molecular biology of the cell 2006-07, Vol.17 (7), p.3329-3344
Hauptverfasser:	Robert, Amélie, Smadja-Lamère, Nicolas, Landry, Marie-Claude, Champagne, Claudia, Petrie, Ryan, Lamarche-Vane, Nathalie, Hosoya, Hiroshi, Lavoie, Josée N
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - antagonists & inhibitors Actins - metabolism Animals Apoptosis - genetics cdc42 GTP-Binding Protein - antagonists & inhibitors cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Nucleus - metabolism Endosomes - metabolism Enzyme Activation Humans Myosin Type II - metabolism Neoplasms - genetics Neoplasms - metabolism rac1 GTP-Binding Protein - antagonists & inhibitors rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology src-Family Kinases - metabolism Transport Vesicles - enzymology Transport Vesicles - physiology Tumor Cells, Cultured Viral Proteins - genetics Viral Proteins - metabolism
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