Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies

Cajal bodies (CBs) have been implicated in the nuclear phase of the biogenesis of spliceosomal U small nuclear ribonucleoproteins (U snRNPs). Here, we have investigated the distribution of the CB marker protein coilin, U snRNPs, and proteins present in C/D box small nucleolar (sno)RNPs in cells depl...

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Veröffentlicht in:	Molecular biology of the cell 2006-07, Vol.17 (7), p.3221-3231
Hauptverfasser:	Lemm, Ira, Girard, Cyrille, Kuhn, Andreas N, Watkins, Nicholas J, Schneider, Marc, Bordonné, Rémy, Lührmann, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Nucleus - chemistry Cell Nucleus - ultrastructure Coiled Bodies - chemistry Coiled Bodies - metabolism Coiled Bodies - ultrastructure Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors Cyclic AMP Response Element-Binding Protein - genetics HeLa Cells Humans Methylation Methyltransferases - antagonists & inhibitors Methyltransferases - genetics Mutation Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nuclear Proteins - analysis Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nucleocytoplasmic Transport Proteins - antagonists & inhibitors Nucleocytoplasmic Transport Proteins - genetics Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Ribonucleoprotein, U4-U6 Small Nuclear - analysis Ribonucleoproteins, Small Nuclear - analysis Ribonucleoproteins, Small Nuclear - biosynthesis RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics SMN Complex Proteins Spliceosomes - metabolism Spliceosomes - ultrastructure
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