Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcel...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2006-06, Vol.103 (23), p.8828-8833 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8833 |
|---|---|
| container_issue | 23 |
| container_start_page | 8828 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 103 |
| creator | Brooksby, Ben Pogue, Brian W. Jiang, Shudong Dehghani, Hamid Srinivasan, Subhadra Kogel, Christine Tosteson, Tor D. Weaver, John Poplack, Steven P. Paulsen, Keith D. |
| description | Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images. |
| doi_str_mv | 10.1073/pnas.0509636103 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1482663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30050274</jstor_id><sourcerecordid>30050274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c590t-599a6343ba732b390e68528fb0dd76bb11fa327be8f50e6deaa86a76011016f23</originalsourceid><addsrcrecordid>eNqFkkFv1DAQhS0EosvCmRNgcUBc0o7txHEuSKWi7UotSHR7tuzESb1K4tROEHvll-Owqy5wgJPtmW-e3owHoZcEjgnk7GToVTiGDArOOAH2CC0IFCThaQGP0QKA5olIaXqEnoWwAYAiE_AUHRGeM8IZW6Afq041tm_wR29UGPFpZQcXDFZ9hc-t9q5p43VqlcdrG8Jk8LVrTfkrcGObXo2TNwHrLb4Ns8zlVntb4euvq-RispWp8GejfLLqa698fN0Mphy9avHada7xarjbPkdPatUG82J_LtHt-af12WVy9eVidXZ6lZRZAWOSFYXiLGVa5YxqVoDhIqOi1lBVOdeakFoxmmsj6izmKqOU4CrnQAgQXlO2RB92usOkO1OVpp-NyMHbTvmtdMrKPzO9vZON-yZJKiiP01qid3sB7-4nE0bZ2VCaNk7IuClILiCjM7lEb_8CN27yfWxOUiCMc5IV_4NYSsWsdLKDSu9C8KZ-sEtAzhsg5w2Qhw2IFa9_7_LA7788Au_3wFx5kGOSMikEFbKe2nY038eIvvk3GolXO2ITRucfEAbREc1T9hOOLc8t</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201334286</pqid></control><display><type>article</type><title>Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Brooksby, Ben ; Pogue, Brian W. ; Jiang, Shudong ; Dehghani, Hamid ; Srinivasan, Subhadra ; Kogel, Christine ; Tosteson, Tor D. ; Weaver, John ; Poplack, Steven P. ; Paulsen, Keith D.</creator><creatorcontrib>Brooksby, Ben ; Pogue, Brian W. ; Jiang, Shudong ; Dehghani, Hamid ; Srinivasan, Subhadra ; Kogel, Christine ; Tosteson, Tor D. ; Weaver, John ; Poplack, Steven P. ; Paulsen, Keith D.</creatorcontrib><description>Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0509636103</identifier><identifier>PMID: 16731633</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adipose Tissue - cytology ; Adipose tissues ; Aged ; Biological Sciences ; Body tissues ; Breast - cytology ; Breasts ; Density ; Female ; Hemoglobin ; Hemoglobins ; Hemoglobins - metabolism ; Humans ; Image Processing, Computer-Assisted ; Image reconstruction ; Imaging ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Middle Aged ; Molecular structure ; NMR ; Nuclear magnetic resonance ; Oxygen ; Physical Sciences ; Spectroscopy, Near-Infrared - methods ; Tissues ; Tomography ; Tomography - methods ; Water</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (23), p.8828-8833</ispartof><rights>Copyright 2006 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Jun 6, 2006</rights><rights>2006 by The National Academy of Sciences of the USA 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-599a6343ba732b390e68528fb0dd76bb11fa327be8f50e6deaa86a76011016f23</citedby><cites>FETCH-LOGICAL-c590t-599a6343ba732b390e68528fb0dd76bb11fa327be8f50e6deaa86a76011016f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/103/23.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30050274$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30050274$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16731633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brooksby, Ben</creatorcontrib><creatorcontrib>Pogue, Brian W.</creatorcontrib><creatorcontrib>Jiang, Shudong</creatorcontrib><creatorcontrib>Dehghani, Hamid</creatorcontrib><creatorcontrib>Srinivasan, Subhadra</creatorcontrib><creatorcontrib>Kogel, Christine</creatorcontrib><creatorcontrib>Tosteson, Tor D.</creatorcontrib><creatorcontrib>Weaver, John</creatorcontrib><creatorcontrib>Poplack, Steven P.</creatorcontrib><creatorcontrib>Paulsen, Keith D.</creatorcontrib><title>Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.</description><subject>Adipose Tissue - cytology</subject><subject>Adipose tissues</subject><subject>Aged</subject><subject>Biological Sciences</subject><subject>Body tissues</subject><subject>Breast - cytology</subject><subject>Breasts</subject><subject>Density</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Image reconstruction</subject><subject>Imaging</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Middle Aged</subject><subject>Molecular structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxygen</subject><subject>Physical Sciences</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Tissues</subject><subject>Tomography</subject><subject>Tomography - methods</subject><subject>Water</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhS0EosvCmRNgcUBc0o7txHEuSKWi7UotSHR7tuzESb1K4tROEHvll-Owqy5wgJPtmW-e3owHoZcEjgnk7GToVTiGDArOOAH2CC0IFCThaQGP0QKA5olIaXqEnoWwAYAiE_AUHRGeM8IZW6Afq041tm_wR29UGPFpZQcXDFZ9hc-t9q5p43VqlcdrG8Jk8LVrTfkrcGObXo2TNwHrLb4Ns8zlVntb4euvq-RispWp8GejfLLqa698fN0Mphy9avHada7xarjbPkdPatUG82J_LtHt-af12WVy9eVidXZ6lZRZAWOSFYXiLGVa5YxqVoDhIqOi1lBVOdeakFoxmmsj6izmKqOU4CrnQAgQXlO2RB92usOkO1OVpp-NyMHbTvmtdMrKPzO9vZON-yZJKiiP01qid3sB7-4nE0bZ2VCaNk7IuClILiCjM7lEb_8CN27yfWxOUiCMc5IV_4NYSsWsdLKDSu9C8KZ-sEtAzhsg5w2Qhw2IFa9_7_LA7788Au_3wFx5kGOSMikEFbKe2nY038eIvvk3GolXO2ITRucfEAbREc1T9hOOLc8t</recordid><startdate>20060606</startdate><enddate>20060606</enddate><creator>Brooksby, Ben</creator><creator>Pogue, Brian W.</creator><creator>Jiang, Shudong</creator><creator>Dehghani, Hamid</creator><creator>Srinivasan, Subhadra</creator><creator>Kogel, Christine</creator><creator>Tosteson, Tor D.</creator><creator>Weaver, John</creator><creator>Poplack, Steven P.</creator><creator>Paulsen, Keith D.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060606</creationdate><title>Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography</title><author>Brooksby, Ben ; Pogue, Brian W. ; Jiang, Shudong ; Dehghani, Hamid ; Srinivasan, Subhadra ; Kogel, Christine ; Tosteson, Tor D. ; Weaver, John ; Poplack, Steven P. ; Paulsen, Keith D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-599a6343ba732b390e68528fb0dd76bb11fa327be8f50e6deaa86a76011016f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adipose Tissue - cytology</topic><topic>Adipose tissues</topic><topic>Aged</topic><topic>Biological Sciences</topic><topic>Body tissues</topic><topic>Breast - cytology</topic><topic>Breasts</topic><topic>Density</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Hemoglobins</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Image reconstruction</topic><topic>Imaging</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Middle Aged</topic><topic>Molecular structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxygen</topic><topic>Physical Sciences</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Tissues</topic><topic>Tomography</topic><topic>Tomography - methods</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brooksby, Ben</creatorcontrib><creatorcontrib>Pogue, Brian W.</creatorcontrib><creatorcontrib>Jiang, Shudong</creatorcontrib><creatorcontrib>Dehghani, Hamid</creatorcontrib><creatorcontrib>Srinivasan, Subhadra</creatorcontrib><creatorcontrib>Kogel, Christine</creatorcontrib><creatorcontrib>Tosteson, Tor D.</creatorcontrib><creatorcontrib>Weaver, John</creatorcontrib><creatorcontrib>Poplack, Steven P.</creatorcontrib><creatorcontrib>Paulsen, Keith D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brooksby, Ben</au><au>Pogue, Brian W.</au><au>Jiang, Shudong</au><au>Dehghani, Hamid</au><au>Srinivasan, Subhadra</au><au>Kogel, Christine</au><au>Tosteson, Tor D.</au><au>Weaver, John</au><au>Poplack, Steven P.</au><au>Paulsen, Keith D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2006-06-06</date><risdate>2006</risdate><volume>103</volume><issue>23</issue><spage>8828</spage><epage>8833</epage><pages>8828-8833</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>16731633</pmid><doi>10.1073/pnas.0509636103</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (23), p.8828-8833 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1482663 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adipose Tissue - cytology Adipose tissues Aged Biological Sciences Body tissues Breast - cytology Breasts Density Female Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Image Processing, Computer-Assisted Image reconstruction Imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Middle Aged Molecular structure NMR Nuclear magnetic resonance Oxygen Physical Sciences Spectroscopy, Near-Infrared - methods Tissues Tomography Tomography - methods Water |
| title | Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T13%3A12%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Imaging%20Breast%20Adipose%20and%20Fibroglandular%20Tissue%20Molecular%20Signatures%20by%20Using%20Hybrid%20MRI-Guided%20Near-Infrared%20Spectral%20Tomography&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Brooksby,%20Ben&rft.date=2006-06-06&rft.volume=103&rft.issue=23&rft.spage=8828&rft.epage=8833&rft.pages=8828-8833&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0509636103&rft_dat=%3Cjstor_pubme%3E30050274%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201334286&rft_id=info:pmid/16731633&rft_jstor_id=30050274&rfr_iscdi=true |