TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF GADOLINIUM AND SAMARIUM CHLORIDES

TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF GADOLINIUM AND SAMARIUM CHLORIDES

A study has been made of the toxicology and pharmacology of gadolinium and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injection are described. The chronic oral ingestion of both chemicals for 12 weeks produced no effects on growth or the blood picture, and only the...

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Veröffentlicht in:British Journal of Pharmacology 1961-12, Vol.17 (3), p.526-532
Hauptverfasser: HALEY, T. J., RAYMOND, K., KOMESU, N., UPHAM, H. C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chlorides
Cosmetics
Elements - pharmacology
Gadolinium
Male
Rats
Samarium
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container_issue 3
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container_title British Journal of Pharmacology
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creator HALEY, T. J.
RAYMOND, K.
KOMESU, N.
UPHAM, H. C.
description A study has been made of the toxicology and pharmacology of gadolinium and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injection are described. The chronic oral ingestion of both chemicals for 12 weeks produced no effects on growth or the blood picture, and only the male rats receiving gadolinium chloride showed liver damage. The pharmacological responses to both chemicals were mainly depressant on all systems studied, and death was associated with cardiovascular collapse coupled with respiratory paralysis. The greatest damage seen was on abraded skin, where non‐healing ulcers were produced by both chemicals, whereas irritation of intact skin and ocular tissues was only transient in nature.
doi_str_mv 10.1111/j.1476-5381.1961.tb01139.x
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subjects Animals
Chlorides
Cosmetics
Elements - pharmacology
Gadolinium
Male
Rats
Samarium
title TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF GADOLINIUM AND SAMARIUM CHLORIDES
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