Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state

MUC1 is a mucin-like type 1 transmembrane protein associated with the apical surface of epithelial cells. In human tumors of epithelial origin MUC1 is overexpressed in an underglycosylated form with truncated O-glycans and accumulates in intracellular compartments. To understand the basis for this a...

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Veröffentlicht in:	Molecular biology of the cell 2000-03, Vol.11 (3), p.819-831
Hauptverfasser:	Altschuler, Y, Kinlough, C L, Poland, P A, Bruns, J B, Apodaca, G, Weisz, O A, Hughey, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Clathrin - physiology Cricetinae Dynamin I Dynamins Endocytosis - physiology Glycosylation GTP Phosphohydrolases - physiology Humans Mucin-1 - metabolism Receptors, Polymeric Immunoglobulin - metabolism
Online-Zugang:	Volltext
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