Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylation

In many cases, gene repression mediated by CpG methylation has been demonstrated. Two different mechanisms have been postulated to explain the repressive effect of methylated CpG DNA: establishment of a repressive chromatin configuration and inhibition of DNA binding of transactivating factors. Usin...

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Veröffentlicht in:	Nucleic acids research 1998-12, Vol.26 (23), p.5256-5260
Hauptverfasser:	Ammerpohl, Ole, Schmitz, Alexander, Steinmüller, Lars, Renkawitz, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cell Line DNA Methylation Enhancer Elements, Genetic - physiology Enzyme Repression - genetics Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones - metabolism Mice Muramidase - biosynthesis Muramidase - genetics Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism
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