Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus

We have demonstrated that the human eosinophilderived neurotoxin (EDN, RNase 2), a rapidly evolving secretory protein derived from eosinophilic leukocytes, mediates the ribonucleolytic destruction of extracellular virions of the single-stranded RNA virus respiratory syncytial virus (RSV). While RNas...

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Veröffentlicht in:	Nucleic acids research 1998-12, Vol.26 (23), p.5327-5332
Hauptverfasser:	Domachowske, Joseph B., Bonville, Cynthia A., Dyer, Kimberly D., Rosenberg, Helene F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antiviral Agents - genetics Antiviral Agents - pharmacology Antiviral Agents - physiology Aotidae Endoribonucleases - genetics Endoribonucleases - physiology Eosinophil-Derived Neurotoxin Evolution, Molecular Extracellular Space - enzymology Extracellular Space - virology Human respiratory syncytial virus Humans Macaca fascicularis Molecular Sequence Data Pongo pygmaeus Proteins - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology Respiratory syncytial virus Respiratory Syncytial Virus, Human - drug effects Respiratory Syncytial Virus, Human - enzymology Ribonuclease, Pancreatic - genetics Ribonuclease, Pancreatic - metabolism Ribonucleases Saguinus Virion - physiology
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