Evolutionary conservation of histone macroH2A subtypes and domains
Histone macroH2A is an unusual core histone that contains a large non-histone region, and a region that resembles a full length H2A. We examined the conservation of this novel structural arrangement by cloning chicken macroH2A cDNAs and comparing them to their rat counterparts. The amino acid sequen...
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| Veröffentlicht in: | Nucleic acids research 1998-06, Vol.26 (12), p.2837-2842 |
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| creator | Pehrson, John R Fuji, Reina N |
| description | Histone macroH2A is an unusual core histone that contains a large non-histone region, and a region that resembles a full length H2A. We examined the conservation of this novel structural arrangement by cloning chicken macroH2A cDNAs and comparing them to their rat counterparts. The amino acid sequences of the two known macroH2A subtypes are >95% identical between these species despite evolutionary separation of ~300 million years. The H2A region of macroH2A is completely conserved, and thus is even more conserved than conventional H2A in these species. The origin of the non-histone domain was examined by comparing its sequence to proteins found in bacteria and RNA viruses. These comparisons indicate that this domain is derived from a gene that originated prior to the appearance of eukaryotes, and suggest that the non-histone region has retained the basic function of its ancestral gene. |
| doi_str_mv | 10.1093/nar/26.12.2837 |
| format | Article |
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Fuji, Reina N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-7e8f8c8ede536a9d5c5a54c45d909008742239639161d94262611ed312bda25c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>blood</topic><topic>Chickens</topic><topic>Cloning, Molecular</topic><topic>complementary DNA</topic><topic>Conserved Sequence - genetics</topic><topic>DNA, Complementary - genetics</topic><topic>Evolution, Molecular</topic><topic>genbank/af058444</topic><topic>genbank/af058445</topic><topic>genbank/af058446</topic><topic>gene expression</topic><topic>histones</topic><topic>Histones - blood</topic><topic>Histones - genetics</topic><topic>liver</topic><topic>Liver - chemistry</topic><topic>Molecular Sequence Data</topic><topic>nucleotide sequences</topic><topic>Phylogeny</topic><topic>Rats</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>species differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pehrson, John R</creatorcontrib><creatorcontrib>Fuji, Reina N</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pehrson, John R</au><au>Fuji, Reina N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolutionary conservation of histone macroH2A subtypes and domains</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Research</addtitle><date>1998-06-15</date><risdate>1998</risdate><volume>26</volume><issue>12</issue><spage>2837</spage><epage>2842</epage><pages>2837-2842</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><abstract>Histone macroH2A is an unusual core histone that contains a large non-histone region, and a region that resembles a full length H2A. 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| ispartof | Nucleic acids research, 1998-06, Vol.26 (12), p.2837-2842 |
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| subjects | Amino Acid Sequence amino acid sequences Animals Base Sequence blood Chickens Cloning, Molecular complementary DNA Conserved Sequence - genetics DNA, Complementary - genetics Evolution, Molecular genbank/af058444 genbank/af058445 genbank/af058446 gene expression histones Histones - blood Histones - genetics liver Liver - chemistry Molecular Sequence Data nucleotide sequences Phylogeny Rats Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid species differences |
| title | Evolutionary conservation of histone macroH2A subtypes and domains |
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