Exploratory studies on azole carboxamides as nucleobase analogs: Thermal denaturation studies on oligodeoxyribonucleotide duplexes containing pyrrole-3-carboxamide

In order to study base pairing properties of the amide group in DNA duplexes, a nucleoside analog, 1-(2′-deoxy-β-d-ribofuranosyl)pyrrole-3-carboxamide, was synthesized by a new route from the ester, methyl 1-(2′-deoxy-3′, 5′-di-O-p-toluoyl-β-d-erythro-pentofuranosyl) pyrrole-3-carboxylate, obtained...

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Veröffentlicht in:	Nucleic acids research 1998-05, Vol.26 (9), p.2208-2215
Hauptverfasser:	Zhang, Peiming, Johnson, W. Travis, Klewer, Douglas, Paul, Natasha, Hoops, Geoffrey, Davisson, V.J., Bergstrom, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoles - chemistry Computer Simulation DNA - chemistry Hot Temperature Hydrogen Bonding Models, Chemical Models, Molecular Nucleic Acid Conformation Nucleic Acid Denaturation Oligodeoxyribonucleotides - chemistry Pyrroles - chemistry Thermodynamics
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