Immunological Studies on Mice Exposed Subacutely to Methyl Isocyanate

The immunotoxicity of methyl isocyanate (MIC) was evaluated in female B6C3F1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on 4 consecutive days. The antibody response to sheep erythrocytes and natural killer cell activity were found to be unaffected by MIC exposure. Although lympho...

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Veröffentlicht in:	Environ. Health Perspect.; (United States) 1987-06, Vol.72, p.139-141
Hauptverfasser:	Tucker, Anne N., Bucher, John R., Germolec, Dori R., Silver, Marianne T., Vore, Stephen J., Luster, Michael I.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS ANIMALS Antibody Formation - drug effects BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Chemical hazards CONNECTIVE TISSUE CELLS Cyanates - administration & dosage Cyanates - toxicity Cytotoxicity, Immunologic - drug effects DISEASE RESISTANCE DISEASES DOSE-RESPONSE RELATIONSHIPS ERYTHROCYTES Female FEMALES Immune System - drug effects IMMUNOLOGY INFECTIOUS DISEASES INFLUENZA VIRUSES INHALATION INTAKE ISOCYANATES Killer Cells, Natural - drug effects LEUKOCYTES Lymphocyte Activation - drug effects Lymphocyte Culture Test, Mixed LYMPHOCYTES MAMMALS MATERIALS MICE MICROORGANISMS Mitogens Mortality Parasite hosts PARASITES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RODENTS SOMATIC CELLS The Toxicity of Methyl Isocyanate. March 12-13, 1986. Research Triangle Park, NC Tumors VERTEBRATES VIRUSES
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