Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury
The intracellular compartmentation of essential and toxic metals is of intense scientific interest because of its potential for adding to our understanding of both normal homeostatic mechanisms for metals and of the mechanisms which underlie metal-induced cell injury. High-affinity metal-binding pro...
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| Veröffentlicht in: | Environ. Health Perspect.; (United States) 1987-04, Vol.71, p.121-128 |
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| description | The intracellular compartmentation of essential and toxic metals is of intense scientific interest because of its potential for adding to our understanding of both normal homeostatic mechanisms for metals and of the mechanisms which underlie metal-induced cell injury. High-affinity metal-binding proteins, lysosomes, and precipitates such as inclusion bodies or concretions, play major roles in the regulation of divalent-metal cation bioavailability. The contribution of a given compartment toward metal homeostasis is dependent upon the level exposure, cell type, organ, species, and life cycle of the organism. Toxic metals may move between these compartments, but the rates and determinants of such exchanges have not been characterized. Available data clearly indicate that sequestration of toxic metals in these specialized compartments can produce profound disturbances in the subcellular handling of essential metals. Further studies of the mechanisms by which metals partition and/or transfer among these compartments are essential to understand and predict toxicity of this important class of toxic agents. |
| doi_str_mv | 10.1289/ehp.8771121 |
| format | Article |
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High-affinity metal-binding proteins, lysosomes, and precipitates such as inclusion bodies or concretions, play major roles in the regulation of divalent-metal cation bioavailability. The contribution of a given compartment toward metal homeostasis is dependent upon the level exposure, cell type, organ, species, and life cycle of the organism. Toxic metals may move between these compartments, but the rates and determinants of such exchanges have not been characterized. Available data clearly indicate that sequestration of toxic metals in these specialized compartments can produce profound disturbances in the subcellular handling of essential metals. Further studies of the mechanisms by which metals partition and/or transfer among these compartments are essential to understand and predict toxicity of this important class of toxic agents.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.8771121</identifier><identifier>PMID: 3297654</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ANIMALS ; AQUATIC ORGANISMS ; BIOLOGICAL AVAILABILITY ; Brackish ; Cadmium ; Carrier proteins ; Cell Survival - drug effects ; Chemical hazards ; CONTAMINATION ; ELEMENTS ; Environmental Pollutants - toxicity ; Epithelial cells ; FISHES ; Fishes - metabolism ; Freshwater ; HOMEOSTASIS ; Inclusion bodies ; Kidneys ; Lead ; Lysosomes ; Mammals ; Marine ; Mechanisms of Pollutant Action in Aquatic Organisms. May 21-23, 1986. Research Triangle Park, NC ; METALS ; Metals - metabolism ; Metals - toxicity ; POLLUTION ; Proteins ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RESPONSE MODIFYING FACTORS ; TOXICITY ; VERTEBRATES ; WATER POLLUTION</subject><ispartof>Environ. Health Perspect.; (United States), 1987-04, Vol.71, p.121-128</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3781-38906a71dfccc0b844c74821227e659ac2073dd08b258e57d1d02198b863d373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3430419$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3430419$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,309,310,314,727,780,784,789,790,803,864,885,23929,23930,25139,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3297654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6271795$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><contributor>Pritchard, JB</contributor><creatorcontrib>Fowler, Bruce A.</creatorcontrib><creatorcontrib>National Institute of Environmental Health Sciences, Research Triangle Park, NC</creatorcontrib><title>Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury</title><title>Environ. Health Perspect.; (United States)</title><addtitle>Environ Health Perspect</addtitle><description>The intracellular compartmentation of essential and toxic metals is of intense scientific interest because of its potential for adding to our understanding of both normal homeostatic mechanisms for metals and of the mechanisms which underlie metal-induced cell injury. High-affinity metal-binding proteins, lysosomes, and precipitates such as inclusion bodies or concretions, play major roles in the regulation of divalent-metal cation bioavailability. The contribution of a given compartment toward metal homeostasis is dependent upon the level exposure, cell type, organ, species, and life cycle of the organism. Toxic metals may move between these compartments, but the rates and determinants of such exchanges have not been characterized. Available data clearly indicate that sequestration of toxic metals in these specialized compartments can produce profound disturbances in the subcellular handling of essential metals. Further studies of the mechanisms by which metals partition and/or transfer among these compartments are essential to understand and predict toxicity of this important class of toxic agents.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ANIMALS</subject><subject>AQUATIC ORGANISMS</subject><subject>BIOLOGICAL AVAILABILITY</subject><subject>Brackish</subject><subject>Cadmium</subject><subject>Carrier proteins</subject><subject>Cell Survival - drug effects</subject><subject>Chemical hazards</subject><subject>CONTAMINATION</subject><subject>ELEMENTS</subject><subject>Environmental Pollutants - toxicity</subject><subject>Epithelial cells</subject><subject>FISHES</subject><subject>Fishes - metabolism</subject><subject>Freshwater</subject><subject>HOMEOSTASIS</subject><subject>Inclusion bodies</subject><subject>Kidneys</subject><subject>Lead</subject><subject>Lysosomes</subject><subject>Mammals</subject><subject>Marine</subject><subject>Mechanisms of Pollutant Action in Aquatic Organisms. May 21-23, 1986. Research Triangle Park, NC</subject><subject>METALS</subject><subject>Metals - metabolism</subject><subject>Metals - toxicity</subject><subject>POLLUTION</subject><subject>Proteins</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RESPONSE MODIFYING FACTORS</subject><subject>TOXICITY</subject><subject>VERTEBRATES</subject><subject>WATER POLLUTION</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxUVpSbdpTz0XTCm9FKcaSdZHDoWw9GMhIVByF1pZm9ViSxtJLuS_r1wvIT0J5r35aWYeQu8BXwCR6qvbHy-kEAAEXqAVdB1plSLsJVphrKDlgnev0ZucDxhjkJyfoTNKVK2yFTKbUJKxbhimwaRmHcejSWV0oZjiY2jirrlxxQy58aG5ephq1Ta36d4En8d82fyOg_un3Ti7X4pzz7oCm004TOnxLXq1q_3u3ek9R3c_vt-tf7XXtz8366vr1lIhoaVSYW4E9DtrLd5KxqxgkgAhwvFOGUuwoH2P5ZZ00nWihx4TUHIrOe2poOfo24I9TtvR9dbNew36mPxo0qOOxuv_leD3-j7-0cAEo52qgI8LIObidba-1I1sDMHZojkRIFRXTZ9Pv6T4MLlc9OjzfD0TXJxyhXEpKJ9pXxajTTHn5HZPkwDWc2q6pqZPqVX3h-fDP3lPMVX906IfconpOYpQLDRlFDNQ9C9gaJ6e</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Fowler, Bruce A.</creator><general>National Institute of Environmental Health Sciences. 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Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19870401</creationdate><title>Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury</title><author>Fowler, Bruce A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3781-38906a71dfccc0b844c74821227e659ac2073dd08b258e57d1d02198b863d373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ANIMALS</topic><topic>AQUATIC ORGANISMS</topic><topic>BIOLOGICAL AVAILABILITY</topic><topic>Brackish</topic><topic>Cadmium</topic><topic>Carrier proteins</topic><topic>Cell Survival - drug effects</topic><topic>Chemical hazards</topic><topic>CONTAMINATION</topic><topic>ELEMENTS</topic><topic>Environmental Pollutants - toxicity</topic><topic>Epithelial cells</topic><topic>FISHES</topic><topic>Fishes - metabolism</topic><topic>Freshwater</topic><topic>HOMEOSTASIS</topic><topic>Inclusion bodies</topic><topic>Kidneys</topic><topic>Lead</topic><topic>Lysosomes</topic><topic>Mammals</topic><topic>Marine</topic><topic>Mechanisms of Pollutant Action in Aquatic Organisms. May 21-23, 1986. Research Triangle Park, NC</topic><topic>METALS</topic><topic>Metals - metabolism</topic><topic>Metals - toxicity</topic><topic>POLLUTION</topic><topic>Proteins</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RESPONSE MODIFYING FACTORS</topic><topic>TOXICITY</topic><topic>VERTEBRATES</topic><topic>WATER POLLUTION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fowler, Bruce A.</creatorcontrib><creatorcontrib>National Institute of Environmental Health Sciences, Research Triangle Park, NC</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environ. Health Perspect.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fowler, Bruce A.</au><au>Pritchard, JB</au><aucorp>National Institute of Environmental Health Sciences, Research Triangle Park, NC</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury</atitle><jtitle>Environ. Health Perspect.; (United States)</jtitle><addtitle>Environ Health Perspect</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>71</volume><spage>121</spage><epage>128</epage><pages>121-128</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>The intracellular compartmentation of essential and toxic metals is of intense scientific interest because of its potential for adding to our understanding of both normal homeostatic mechanisms for metals and of the mechanisms which underlie metal-induced cell injury. High-affinity metal-binding proteins, lysosomes, and precipitates such as inclusion bodies or concretions, play major roles in the regulation of divalent-metal cation bioavailability. The contribution of a given compartment toward metal homeostasis is dependent upon the level exposure, cell type, organ, species, and life cycle of the organism. Toxic metals may move between these compartments, but the rates and determinants of such exchanges have not been characterized. Available data clearly indicate that sequestration of toxic metals in these specialized compartments can produce profound disturbances in the subcellular handling of essential metals. Further studies of the mechanisms by which metals partition and/or transfer among these compartments are essential to understand and predict toxicity of this important class of toxic agents.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>3297654</pmid><doi>10.1289/ehp.8771121</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environ. Health Perspect.; (United States), 1987-04, Vol.71, p.121-128 |
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| source | PubMed Central (Open Access); MEDLINE; DOAJ Directory of Open Access Journals; JSTOR; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | 560300 - Chemicals Metabolism & Toxicology ANIMALS AQUATIC ORGANISMS BIOLOGICAL AVAILABILITY Brackish Cadmium Carrier proteins Cell Survival - drug effects Chemical hazards CONTAMINATION ELEMENTS Environmental Pollutants - toxicity Epithelial cells FISHES Fishes - metabolism Freshwater HOMEOSTASIS Inclusion bodies Kidneys Lead Lysosomes Mammals Marine Mechanisms of Pollutant Action in Aquatic Organisms. May 21-23, 1986. Research Triangle Park, NC METALS Metals - metabolism Metals - toxicity POLLUTION Proteins RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESPONSE MODIFYING FACTORS TOXICITY VERTEBRATES WATER POLLUTION |
| title | Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury |
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