The contribution of TRPM8 channels to cold sensing in mammalian neurones

Different classes of ion channels have been implicated in sensing cold temperatures at mammalian thermoreceptor nerve endings. A major candidate is TRPM8, a non-selective cation channel of the transient receptor potential family, activated by menthol and low temperatures. We investigated the role of...

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Veröffentlicht in:	The Journal of physiology 2005-09, Vol.567 (2), p.415-426
Hauptverfasser:	De La Peña, Elvira, Mälkiä, Annika, Cabedo, Hugo, Belmonte, Carlos, Viana, Félix
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Physiology Cells, Cultured Cold Temperature Hippocampus - physiology Humans Ion Channels - genetics Ion Channels - metabolism Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neurons, Afferent - physiology Thermosensing - physiology Transfection TRPM Cation Channels
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