Online System for Faster Multipoint Linkage Analysis via Parallel Execution on Thousands of Personal Computers

Computation of LOD scores is a valuable tool for mapping disease-susceptibility genes in the study of Mendelian and complex diseases. However, computation of exact multipoint likelihoods of large inbred pedigrees with extensive missing data is often beyond the capabilities of a single computer. We p...

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Veröffentlicht in:	American journal of human genetics 2006-06, Vol.78 (6), p.922-935
Hauptverfasser:	Silberstein, M., Tzemach, A., Dovgolevsky, N., Fishelson, M., Schuster, A., Geiger, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences Classical genetics, quantitative genetics, hybrids Disease Fundamental and applied biological sciences. Psychology General aspects. Genetic counseling Genetic algorithms Genetic Linkage Genetic research Genetics of eukaryotes. Biological and molecular evolution Human Humans Lod Score Medical genetics Medical sciences Microcomputers - utilization Molecular and cellular biology Online Systems - utilization Optimization techniques Pedigree Studies
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