Sox10 Regulates Ciliary Neurotrophic Factor Gene Expression in Schwann Cells

Ciliary neurotrophic factor (Cntf) plays an essential role in postnatal maintenance of spinal motoneurons. Whereas the expression of this neurotrophic factor is low during embryonic development, it is highly up-regulated after birth in myelinating Schwann cells of rodents. To characterize the underl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-05, Vol.103 (20), p.7871-7876
Hauptverfasser:	Ito, Yasuhiro, Wiese, Stefan, Funk, Natalja, Chittka, Alexandra, Rossoll, Wilfried, Bömmel, Heike, Watabe, Kazuhiko, Wegner, Michael, Sendtner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological Sciences Cell Line Cell lines Cells Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Gene Expression Regulation Genes Genes, Reporter High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Mice Nervous system Neurons Neurosciences NIH 3T3 cells Peripheral nervous system diseases Promoter Regions, Genetic Rats Reporter genes Rodents Schwann cells Schwann Cells - cytology Schwann Cells - physiology Sciatic Nerve - cytology Sciatic Nerve - metabolism SOXE Transcription Factors Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription Initiation Site Transfection Up regulation
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