Allelic Silencing at the Tumor-Suppressor Locus 13q14.3 Suggests an Epigenetic Tumor-Suppressor Mechanism

Genomic material from chromosome band 13q14.3 distal to the retinoblastoma locus is recurrently lost in a variety of human neoplasms, indicating an as-yet-unidentified tumor-suppressor mechanism. No pathogenic mutations have been found in the minimally deleted region until now. However, in B cell ch...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-05, Vol.103 (20), p.7741-7746
Hauptverfasser:	Mertens, Daniel, Wolf, Stephan, Tschuch, Cordula, Mund, Cora, Kienle, Dirk, Ohl, Sibylle, Schroeter, Petra, Lyko, Frank, Döhner, Hartmut, Stilgenbauer, Stephan, Lichter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles B lymphocytes Base Sequence Biological Sciences Cell Line Cell lines Chromatin Chromosomes Chromosomes, Human, Pair 13 - genetics CpG Islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Epigenetics Female Gene expression Gene Silencing Genes Genes, Tumor Suppressor Genetic loci Histones Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Lymphocytes - physiology Male Methylation Middle Aged T lymphocytes
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