PKCε Increases Endothelin Converting Enzyme Activity and Reduces Amyloid Plaque Pathology in Transgenic Mice

Deposition of plaques containing amyloid P3 (AP3) peptides is a neuropathological hallmark of Alzheimer's disease (AD). Here we demonstrate that neuronal overexpression of the ε isozyme of PKC decreases Aβ levels, plaque burden, and plaque-associated neuritic dystrophy and reactive astrocytosis...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-05, Vol.103 (21), p.8215-8220
Hauptverfasser:	Choi, Doo-Sup, Wang, Dan, Yu, Gui-Qui, Zhu, Guofen, Kharazia, Viktor N., Paredes, J. Peter, Chang, Wesley S., Deitchman, Jason K., Mucke, Lennart, Messing, Robert O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid plaque Amyloids Antibodies Biological Sciences Brain Enzymes Gene expression regulation Hippocampus Mice Neurons Transgenic animals
Online-Zugang:	Volltext
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