The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes

In an effort to discover novel oligonucleotide modifications for antisense therapeutics, we have prepared oligodeoxyribonucleotides containing more than 200 different modifications and measured their affinities for complementary RNA. These include modifications to the heterocyclic bases, the deoxy-r...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research 1997-11, Vol.25 (22), p.4429-4443
Hauptverfasser:	Freier, Susan M., Altmann, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - metabolism Nucleic Acid Conformation Nucleic Acid Hybridization Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - metabolism Phosphorus - chemistry Purines - chemistry Pyrimidines - chemistry Ribose - chemistry RNA, Complementary - metabolism Structure-Activity Relationship Thymine - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!