Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family
In exposure or risk assessments, both environmental and biological measurements are often used. Environmental measurements are an excellent means for evaluating regulatory compliance, but the models used to estimate body burden from these measurements are complex. Unless all possible routes of expos...
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| Veröffentlicht in: | Environmental health perspectives 1997-05, Vol.105 (5), p.510-513 |
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| creator | Shealy, Dana B. Barr, John R. Ashley, David L. Patterson, Donald G. Camann, David E. Bond, Andrew E. |
| description | In exposure or risk assessments, both environmental and biological measurements are often used. Environmental measurements are an excellent means for evaluating regulatory compliance, but the models used to estimate body burden from these measurements are complex. Unless all possible routes of exposure (i.e., inhalation, dermal absorption, ingestion) are evaluated, exposure to a toxicant can be underestimated. To circumvent this problem, measurements of the internal dose of a toxicant in blood, serum, urine, or tissues can be used singularly or in combination with environmental data for exposure assessment. In three separate laboratories, carbaryl or its primary metabolite, 1-naphthol, was measured in personal air, dermal samples, blood serum, and urine from farmer applicators and their families. The usefulness of both environmental and biological data has been demonstrated. For the farmer applicator, the environmental levels of carbaryl would have been sufficient to determine that an exposure had occurred. However, biological measurements were necessary to determine the absorbed dose of each member of the applicator's family. In addition, a correlation between serum and urinary 1-naphthol measurements has been shown; therefore, either matrix can be used to accurately evaluate occupational carbaryl exposure. |
| doi_str_mv | 10.1289/ehp.97105510 |
| format | Article |
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However, biological measurements were necessary to determine the absorbed dose of each member of the applicator's family. In addition, a correlation between serum and urinary 1-naphthol measurements has been shown; therefore, either matrix can be used to accurately evaluate occupational carbaryl exposure.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.97105510</identifier><identifier>PMID: 9222136</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Agriculture ; Air Pollutants, Occupational - analysis ; Air sampling ; Carbaryl - analysis ; Carbaryl - metabolism ; Chemical hazards ; Correlations ; Crops ; Dosage ; Environmental agencies ; Environmental health ; Environmental Monitoring - methods ; Environmental Monitoring - standards ; Family members ; Humans ; Insecticides - analysis ; Insecticides - metabolism ; Naphthols - blood ; Naphthols - urine ; Pesticides ; Reproducibility of Results ; Skin - chemistry ; Surveys and Questionnaires ; Urine</subject><ispartof>Environmental health perspectives, 1997-05, Vol.105 (5), p.510-513</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-5ed04658df6cb3b3c2683ed70bab2854e1020d9a05e97c47d5264b04b1aed1b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3433579$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3433579$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9222136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shealy, Dana B.</creatorcontrib><creatorcontrib>Barr, John R.</creatorcontrib><creatorcontrib>Ashley, David L.</creatorcontrib><creatorcontrib>Patterson, Donald G.</creatorcontrib><creatorcontrib>Camann, David E.</creatorcontrib><creatorcontrib>Bond, Andrew E.</creatorcontrib><title>Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>In exposure or risk assessments, both environmental and biological measurements are often used. Environmental measurements are an excellent means for evaluating regulatory compliance, but the models used to estimate body burden from these measurements are complex. Unless all possible routes of exposure (i.e., inhalation, dermal absorption, ingestion) are evaluated, exposure to a toxicant can be underestimated. To circumvent this problem, measurements of the internal dose of a toxicant in blood, serum, urine, or tissues can be used singularly or in combination with environmental data for exposure assessment. In three separate laboratories, carbaryl or its primary metabolite, 1-naphthol, was measured in personal air, dermal samples, blood serum, and urine from farmer applicators and their families. The usefulness of both environmental and biological data has been demonstrated. For the farmer applicator, the environmental levels of carbaryl would have been sufficient to determine that an exposure had occurred. However, biological measurements were necessary to determine the absorbed dose of each member of the applicator's family. In addition, a correlation between serum and urinary 1-naphthol measurements has been shown; therefore, either matrix can be used to accurately evaluate occupational carbaryl exposure.</description><subject>Agriculture</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Air sampling</subject><subject>Carbaryl - analysis</subject><subject>Carbaryl - metabolism</subject><subject>Chemical hazards</subject><subject>Correlations</subject><subject>Crops</subject><subject>Dosage</subject><subject>Environmental agencies</subject><subject>Environmental health</subject><subject>Environmental Monitoring - methods</subject><subject>Environmental Monitoring - standards</subject><subject>Family members</subject><subject>Humans</subject><subject>Insecticides - analysis</subject><subject>Insecticides - metabolism</subject><subject>Naphthols - blood</subject><subject>Naphthols - urine</subject><subject>Pesticides</subject><subject>Reproducibility of Results</subject><subject>Skin - chemistry</subject><subject>Surveys and Questionnaires</subject><subject>Urine</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1EVZbCjSuSD6inpoz_Jr4gVauWVipwgJ4tO_ESV04c7KSon4CvXbe7rQoXTiPN-83TzDyE3hE4JrRRH10_HauagBAEXqAVEYJWSlH-Eq0AFKlkLcUr9DrnawAgjZT7aF9RSgmTK_RnHVNywcw-jjhu8Ol441McBzfOJuC1Sdak24C_OJOX5O7bGf_2c4-_u7QM2Iwdvkp-LBAm1Vcz9XMf_8H9iA0-M2lwCZ9MU_CtmWN6GD33uSiDD7dv0N7GhOze7uoBujo7_bE-ry6_fb5Yn1xWLa9hroTrgEvRdBvZWmZZS2XDXFeDNZY2gjsCFDplQDhVl5FOUMktcEuM64hl7AB92vpOix1c15YNkwl6Sn4oN-hovP5bGX2vf8YbTbhUjeTF4HBnkOKvxeVZDz63LgQzurhkTSRQIRr4P8i5IKwWBTzagm2KOSe3edqGgL5PWJeE9WPCBX___IIneBdp0T9s9etc3vzcizKoNeOMiVqxO7CHr_0</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Shealy, Dana B.</creator><creator>Barr, John R.</creator><creator>Ashley, David L.</creator><creator>Patterson, Donald G.</creator><creator>Camann, David E.</creator><creator>Bond, Andrew E.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>5PM</scope></search><sort><creationdate>19970501</creationdate><title>Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family</title><author>Shealy, Dana B. ; Barr, John R. ; Ashley, David L. ; Patterson, Donald G. ; Camann, David E. ; Bond, Andrew E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-5ed04658df6cb3b3c2683ed70bab2854e1020d9a05e97c47d5264b04b1aed1b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Agriculture</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Air sampling</topic><topic>Carbaryl - analysis</topic><topic>Carbaryl - metabolism</topic><topic>Chemical hazards</topic><topic>Correlations</topic><topic>Crops</topic><topic>Dosage</topic><topic>Environmental agencies</topic><topic>Environmental health</topic><topic>Environmental Monitoring - methods</topic><topic>Environmental Monitoring - standards</topic><topic>Family members</topic><topic>Humans</topic><topic>Insecticides - analysis</topic><topic>Insecticides - metabolism</topic><topic>Naphthols - blood</topic><topic>Naphthols - urine</topic><topic>Pesticides</topic><topic>Reproducibility of Results</topic><topic>Skin - chemistry</topic><topic>Surveys and Questionnaires</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shealy, Dana B.</creatorcontrib><creatorcontrib>Barr, John R.</creatorcontrib><creatorcontrib>Ashley, David L.</creatorcontrib><creatorcontrib>Patterson, Donald G.</creatorcontrib><creatorcontrib>Camann, David E.</creatorcontrib><creatorcontrib>Bond, Andrew E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shealy, Dana B.</au><au>Barr, John R.</au><au>Ashley, David L.</au><au>Patterson, Donald G.</au><au>Camann, David E.</au><au>Bond, Andrew E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>105</volume><issue>5</issue><spage>510</spage><epage>513</epage><pages>510-513</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>In exposure or risk assessments, both environmental and biological measurements are often used. Environmental measurements are an excellent means for evaluating regulatory compliance, but the models used to estimate body burden from these measurements are complex. Unless all possible routes of exposure (i.e., inhalation, dermal absorption, ingestion) are evaluated, exposure to a toxicant can be underestimated. To circumvent this problem, measurements of the internal dose of a toxicant in blood, serum, urine, or tissues can be used singularly or in combination with environmental data for exposure assessment. In three separate laboratories, carbaryl or its primary metabolite, 1-naphthol, was measured in personal air, dermal samples, blood serum, and urine from farmer applicators and their families. The usefulness of both environmental and biological data has been demonstrated. For the farmer applicator, the environmental levels of carbaryl would have been sufficient to determine that an exposure had occurred. 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| ispartof | Environmental health perspectives, 1997-05, Vol.105 (5), p.510-513 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Jstor Complete Legacy; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Agriculture Air Pollutants, Occupational - analysis Air sampling Carbaryl - analysis Carbaryl - metabolism Chemical hazards Correlations Crops Dosage Environmental agencies Environmental health Environmental Monitoring - methods Environmental Monitoring - standards Family members Humans Insecticides - analysis Insecticides - metabolism Naphthols - blood Naphthols - urine Pesticides Reproducibility of Results Skin - chemistry Surveys and Questionnaires Urine |
| title | Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family |
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